IFN-gamma Receptor-1, Monoclonal Antibody

Anti-mouse Interferon-gamma R1 [INFgammaR1] (#7K23)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 10; NC_000076.6 (19591958..19610225). Location: 10 A3; 10 8.49 cM

Monoclonal

IgG2

(7K23)

Rat

This antibody detects mouse INFgammaR1 in Western blotting.

Protein A/G affinity chromatography

The IgG fraction of culture supernatant was purified by Protein A/G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS). Lyophilized samples are stable for 2 years from date of receipt when stored at

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.

Manufactured in an ISO 9001:2008 Certified Laboratory.

Small volumes of anti-IFN-gamma Receptor-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The high-affinity IFN-gamma receptor complex is made up of two type I transmembrane proteins, IFN-gamma R1 (IFN-gamma R alpha) and IFN-gamma R2 (IFN-gamma R beta). Both proteins are members of the type II cytokine receptor family. IFN-gamma R1 is the ligand-binding subunit that is necessary and sufficient for IFN-gamma binding and receptor internalization. IFN-gamma R2 is required for IFN-gamma signaling, but does not bind IFN-gamma by itself.

Western Blot (WB)

1. Western blot: Yes (1:500-1000)

52,343 Da

interferon gamma receptor 1

interferon gamma receptor 1; IFN-gamma-R1; INF-g receptor; IFN-gamma receptor 1; interferon-gamma receptor 1

Interferon gamma receptor 1

Ifngr; IFN-gamma receptor 1  [Similar Products]

INGR1_MOUSE

Function: Receptor for interferon gamma. Two receptors bind one interferon gamma dimer.

Subcellular location: Membrane; Single-pass type I membrane protein.

Post-translational modification: Phosphorylated at Ser/Thr residues.

Sequence similarities: Belongs to the type II cytokine receptor family.Contains 2 fibronectin type-III domains.Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Sequence caution: The sequence AAA37895.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

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