Adenylate Cyclase 5, Polyclonal Antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

The antibody is a rabbit polyclonal antibody raised against ADCY5. It has beenselected for its ability to recognize ADCY5 in immunohistochemical staining andwestern blotting.

Affinity Chromatography

Liquid

200ug/ml (lot specific)

Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Small volumes of anti-ADCY5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)

Western blotting: 0.2-2ug/mL;1:250-2500
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.

Western Blot: Sample: Recombinant protein.

DAB staining on fromalin fixed paraffin-embedded Kidney tissue)

102,606 Da

adenylate cyclase 5

adenylate cyclase type 5

Adenylate cyclase type 5

AC5  [Similar Products]

This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

ADCY5: This is a membrane-bound, calcium-inhibitable adenylyl cyclase. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family

Chromosomal Location of Human Ortholog: 3q21.1

Cellular Component: cilium; guanylate cyclase complex, soluble; integral component of membrane; intermediate filament cytoskeleton; plasma membrane

Molecular Function: adenylate cyclase activity; adenylate cyclase binding; ATP binding; guanylate cyclase activity; metal ion binding; protein heterodimerization activity

Biological Process: activation of protein kinase A activity; adenosine receptor signaling pathway; adenylate cyclase activation; adenylate cyclase-activating dopamine receptor signaling pathway; adenylate cyclase-activating G-protein coupled receptor signaling pathway; adenylate cyclase-inhibiting dopamine receptor signaling pathway; cAMP biosynthetic process; cGMP biosynthetic process; elevation of cytosolic calcium ion concentration; G-protein signaling, adenylate cyclase inhibiting pathway; locomotory behavior; neuromuscular process controlling balance; renal water homeostasis

Disease: Dyskinesia, Familial, With Facial Myokymia

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