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b2-Microglobulin, Polyclonal Antibody

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产品名称: b2-Microglobulin, Polyclonal Antibody
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简单介绍

b2-Microglobulin, Polyclonal Antibody


b2-Microglobulin, Polyclonal Antibody  的详细介绍
Product Name

b2-Microglobulin (HLA-G), Polyclonal Antibody

Full Product Name

b2-Microglobulin (B2M)

Product Synonym Names
Anti -b2-Microglobulin (B2M)
Product Gene Name

anti-HLA-G antibody

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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Chromosome Location
Chromosome: 6; NC_000006.11 (29794756..29798899). Location: 6p21.3
3D Structure
ModBase 3D Structure for O02923
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
Rat
Specificity
Recognizes rat b2-Microglobulin. Species Sequence Homology: mouse; 86%, human; 75%
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 500ul sterile PBS.
Immunogen
NS0-derived recombinant rat b2-Microglobulin (aa21-116, Accession #PO7151).
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-HLA-G antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for
anti-HLA-G antibody
Beta-2 microglobulin is a ubiquitous, 12kD, secreted, non-glycosylated protein required for cell surface expression and non-covalent assembly of MHC Class I molecules and CD1 cell surface glycoproteins. Mature rat b2-Microglobulin is a 99aa peptide containing one C1-type lg-like domain (aa 22-116). In human, b2-Microglobulin is known to dissociate from the MHC complex and circulate as full-length and N-terminal-truncated peptides of 93, 91 and 90 amino acids.
Product Categories/Family for anti-HLA-G antibody
Antibodies; Abs to Serum Proteins
Applications Tested/Suitable for anti-HLA-G antibody
ELISA (EL/EIA), Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes for anti-HLA-G antibody
Suitable for use in Direct ELISA, Western Blot and Flow Cytometry.
Dilution: Direct ELISA: 0.5-1.0ug/ml. The detection limit is ~1ng/well.
Western Blot: 0.1-0.2ug/ml. The detection limit is ~1ng/lane under non-reducing and reducing conditions.
Flow Cytometry: 50ug/ml. 10ul labels 1-2.5x10e5 cells in a total reaction volume not exceeding 200ul. Tested on rat splenocytes.
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NCBI/Uniprot data below describe general gene information for HLA-G. It may not necessarily be applicable to this product.
NCBI GI #
188468
NCBI GeneID
3135
UniProt Primary Accession #
O02923 [Other Products]
UniProt Related Accession #
O02923; O02924; O02925; O02926; O02927; O02928; O02929; O19588; O19658; O19659[Other Products]
Molecular Weight
31,549 Da[Similar Products]
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NCBI Official Full Name
b2 microglobulin
NCBI Official Synonym Full Names
major histocompatibility complex, class I, G
NCBI Official Symbol
HLA-G  [Similar Products]
NCBI Official Synonym Symbols
MHC-G
  [Similar Products]
NCBI Protein Information
HLA class I histocompatibility antigen, alpha chain G; HLA G antigen; b2 microglobulin; OTTHUMP00000029218; OTTHUMP00000029220; OTTHUMP00000033527; OTTHUMP00000159507; HLA class I molecule; MHC class I antigen G; HLA-G histocompatibility antigen, class I, G
UniProt Protein Name
HLA-G protein
Protein Family
HLA class I histocompatibility antigen
UniProt Gene Name
HLA-G  [Similar Products]
UniProt Entry Name
O02923_HUMAN
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NCBI Summary for HLA-G
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq]
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UniProt Comments for HLA-G
Sequence similarities: Belongs to the MHC class I family. RuleBase RU004439
Research Articles on HLA-G
1. We found the production of HLA-G and HLA-E in a majority of cases of glioblastoma
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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