Product Name
Adenylate Cyclase 6a (Adcy5), Polyclonal Antibody
Full Product Name
Adenylate Cyclase 6a (ADCY6a)
Product Synonym Names
Anti -Adenylate Cyclase 6a (ADCY6a)
Product Gene Name
anti-Adcy5 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 11; NC_005110.3 (71787104..71933840, complement). Location: 11q22
3D Structure
ModBase 3D Structure for Q04400
Specificity
Recognizes human ADCY6a.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
Immunogen
Synthetic peptide corresponding to aa1-121
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-Adcy5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-Adcy5 antibody
Antibodies; Abs to Enzymes, Cyclase
Applications Tested/Suitable for anti-Adcy5 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-Adcy5 antibody
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:1000-1:2000
NCBI/Uniprot data below describe general gene information for Adcy5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_072122.1
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NCBI GenBank Nucleotide #
NM_022600.1
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UniProt Primary Accession #
Q04400
[Other Products]
UniProt Related Accession #
Q04400[Other Products]
Molecular Weight
139,179 Da[Similar Products]
NCBI Official Full Name
adenylate cyclase type 5
NCBI Official Synonym Full Names
adenylate cyclase 5
NCBI Official Symbol
Adcy5 [Similar Products]
NCBI Protein Information
adenylate cyclase type 5; adenylyl cyclase 5; adenylyl cyclase type V; adenylate cyclase type V; ATP pyrophosphate-lyase 5
UniProt Protein Name
Adenylate cyclase type 5
UniProt Synonym Protein Names
ATP pyrophosphate-lyase 5; Adenylate cyclase type V; Adenylyl cyclase 5
Protein Family
Adenylate cyclase
UniProt Gene Name
Adcy5 [Similar Products]
UniProt Entry Name
ADCY5_RAT
NCBI Summary for Adcy5
enzyme that catalyzes the formation of the secondary messenger cyclic adenosine monophosphate [RGD, Feb 2006]
UniProt Comments for Adcy5
Function: This is a membrane-bound, calcium-inhibitable adenylyl cyclase.
Catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate.
Cofactor: Binds 2 magnesium ions per subunit
By similarity.
Enzyme regulation: Inhibition by calcium in the submicromolar concentration range. Phosphorylation by RAF1 results in its activation
By similarity.
Subunit structure: Part of a complex containing AKAP5, ADCY6, PDE4C and PKD2
By similarity. Interacts with RAF1
By similarity.
Subcellular location: Membrane; Multi-pass membrane protein. Cell projection › cilium
By similarity.
Post-translational modification: Phosphorylated by RAF1
By similarity.
Sequence similarities: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.Contains 2 guanylate cyclase domains.
Research Articles on Adcy5
1. Increased expression of adenylyl cyclases V and VI is a major determinant of increased GABAergic transmission in the substantia nigra pars reticulata of animals in which L-DOPA induces severe dyskinesia.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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