Product Name
b2-Microglobulin (HLA-G), Monoclonal Antibody
Full Product Name
b2-Microglobulin (B2M)
Product Synonym Names
Anti -b2-Microglobulin (B2M)
Product Gene Name
anti-HLA-G antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 6; NC_000006.11 (29794756..29798899). Location: 6p21.3
3D Structure
ModBase 3D Structure for O02923
Specificity
Recognizes b2-Microglobulin (human).
Purity/Purification
Affinity Purified
Purified by Protein A/G affinity chromatography from culture supernatant.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 15mM sodium azide.
Immunogen
Beta2-microglobulin isolated from human plasma.
Hybridoma
P3X63-Ag8.653. Female BALB/c mice immunizided i.p. with immunogen adsorbed onto Al(OH)03.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-HLA-G antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-HLA-G antibody
Antibodies; Abs to Serum Proteins
Applications Tested/Suitable for anti-HLA-G antibody
ELISA (EL/EIA)
Application Notes for anti-HLA-G antibody
Suitable for use inmmunoaffinity purification of beta2-microglobulin(1) and ELISA.
Dilution: ELISA: 1:15,000
NCBI/Uniprot data below describe general gene information for HLA-G. It may not necessarily be applicable to this product.
UniProt Primary Accession #
O02923
[Other Products]
UniProt Related Accession #
O02923; O02924; O02925; O02926; O02927; O02928; O02929; O19588; O19658; O19659[Other Products]
Molecular Weight
31,549 Da[Similar Products]
NCBI Official Full Name
b2 microglobulin
NCBI Official Synonym Full Names
major histocompatibility complex, class I, G
NCBI Official Symbol
HLA-G [Similar Products]
NCBI Official Synonym Symbols
MHC-G
[Similar Products]
NCBI Protein Information
HLA class I histocompatibility antigen, alpha chain G; HLA G antigen; b2 microglobulin; OTTHUMP00000029218; OTTHUMP00000029220; OTTHUMP00000033527; OTTHUMP00000159507; HLA class I molecule; MHC class I antigen G; HLA-G histocompatibility antigen, class I, G
UniProt Protein Name
HLA-G protein
Protein Family
HLA class I histocompatibility antigen
UniProt Gene Name
HLA-G [Similar Products]
UniProt Entry Name
O02923_HUMAN
NCBI Summary for HLA-G
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq]
UniProt Comments for HLA-G
Sequence similarities: Belongs to the MHC class I family. RuleBase RU004439
Research Articles on HLA-G
1. We found the production of HLA-G and HLA-E in a majority of cases of glioblastoma
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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