Full Product Name
LIPA Antibody
Product Synonym Names
LAL; CESD
Product Gene Name
anti-LIPA antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P38571
Specificity
The antibody detects endogenous levels of total LIPA protein.
Purity/Purification
Antigen affinity purification
Form/Format
pH 7.4 PBS, 0.05% NaN3, 40% Glycerol
Concentration
0.7 mg/mL (lot specific)
Immunogen
Fusion protein of human LIPA
Preparation and Storage
Store at -20 degree C.
Other Notes
Small volumes of anti-LIPA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LIPA antibody
This gene encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman disease and cholesteryl ester storage disease. Alternatively spliced transcript variants have been found for this gene.
Product Categories/Family for anti-LIPA antibody
Total protein Ab
Applications Tested/Suitable for anti-LIPA antibody
Immunohistochemistry (IHC)
Application Notes for anti-LIPA antibody
IHC: 1:50-300
Immunohistochemistry (IHC) of anti-LIPA antibody
The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using 47403(LIPA Antibody) at dilution 1/50.(Original magnification: 200)
NCBI/Uniprot data below describe general gene information for LIPA. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000226.2
[Other Products]
NCBI GenBank Nucleotide #
NM_000235.4
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UniProt Primary Accession #
P38571
[Other Products]
UniProt Secondary Accession #
Q16529; Q53H21; Q5T074; Q5T771; Q96EJ0; B2RBH5; D3DR29[Other Products]
UniProt Related Accession #
P38571[Other Products]
Molecular Weight
39,112 Da
NCBI Official Full Name
lysosomal acid lipase/cholesteryl ester hydrolase isoform 1
NCBI Official Synonym Full Names
lipase A, lysosomal acid type
NCBI Official Symbol
LIPA [Similar Products]
NCBI Official Synonym Symbols
LAL; CESD
[Similar Products]
NCBI Protein Information
lysosomal acid lipase/cholesteryl ester hydrolase
UniProt Protein Name
Lysosomal acid lipase/cholesteryl ester hydrolase
UniProt Synonym Protein Names
Cholesteryl esterase; Lipase A; Sterol esterase
UniProt Gene Name
LIPA [Similar Products]
UniProt Synonym Gene Names
Acid cholesteryl ester hydrolase; LAL [Similar Products]
NCBI Summary for LIPA
This gene encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman disease and cholesteryl ester storage disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]
UniProt Comments for LIPA
Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation.
Research Articles on LIPA
1. Report LIPA variants/phenotype in childhood-onset lysosomal acid lipase deficiency.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
