Accn2, Polyclonal Antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Affinity Purified

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-ASIC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This is a rabbit polyclonal antibody against Accn2. It was validated on Western Blot

Target Description: Accn2 is a cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. It also permeable for Ca2+, Li+ and K+. It generates a biphasic current with a fast inactivating and a slow sustained phase and mediates glutamate-independent Ca2+ entry into neurons upon acidosis. This Ca2+ overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Accn2 functions as a postsynaptic proton receptor that influences intracellular Ca2+ concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. It modulates activity in the circuits underlying innate fear.

Polyclonal; Transcription Factor; Ion Channel; Signal Proteins; Cell Biology; Apoptosis; Membrane & Traffic; DNA/RNA/Protein Interactions; Meiosis/Mitosis/Cell Cycle;

Western Blot (WB)

WB Suggested Anti-Accn2 Antibody
Titration: 1.0 ug/ml
Positive Control: Mouse Heart

60kDa

acid-sensing (proton-gated) ion channel 1

acid-sensing ion channel 1

Acid-sensing ion channel 1

Accn2; Asic; Bnac2; ASIC1; BNaC2  [Similar Products]

ASIC1_MOUSE

ASIC1: non-voltage-gated amiloride-sensitive cation channel permeable for sodium, potassium and lithium. A member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Expressed in most if not all brain neurons.

Protein type: Transporter; Membrane protein, multi-pass; Transporter, ion channel; Membrane protein, integral; Channel, cation

Cellular Component: cell surface; membrane; integral to plasma membrane; dendritic spine; integral to membrane; plasma membrane; synapse; dendritic shaft

Molecular Function: amiloride-sensitive sodium channel activity; monovalent inorganic cation transmembrane transporter activity; protein binding; ion gated channel activity; ion channel activity; cation channel activity; sodium channel activity

Biological Process: regulation of membrane potential; transport; calcium ion transport; sodium ion transport; monovalent inorganic cation transport; ion transport; sensory perception of sour taste; response to acidity; cation transport; associative learning; memory; negative regulation of neurotransmitter secretion

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