(Rhesus macaque) Pro-interleukin-16 (IL16), Recombinant Protein

Recombinant (Rhesus macaque) Pro-interleukin-16 (IL16); Pro-interleukin-16 Cleaved into the following chain: 1. Interleukin-16; 2. IL-16; Lymphocyte chemoattractant factor; LCF

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 7; NC_007864.1 (60453557..60464220). Location: chromosome: 7

E Coli or Yeast or Baculovirus or Mammalian Cell

>=90% (lot specific)

Liquid containing glycerol

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterile filter available upon request.

Low endotoxin available upon request.

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of IL16 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

66,563 Da[Similar Products]

pro-interleukin-16; IL-16; interleukin 16 (lymphocyte chemoattractant factor)

Pro-interleukin-16

IL-16; LCF  [Similar Products]

IL16_MACMU

Function: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4

By similarity.Pro-interleukin-16 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells

By similarity.

Subunit structure: Homotetramer

Probable. Pro-interleukin-16 interacts (via PDZ 2 domain) with PPP1R12A, PPP1R12B and PPP1R12C. Pro-interleukin-16 interacts with GRIN2A. Pro-interleukin-16 interacts with GABPB1. Pro-interleukin-16 interacts (via PDZ 3 domain) with HDAC3

By similarity.

Subcellular location: Interleukin-16: Secreted

By similarity. Pro-interleukin-16: Cytoplasm. Nucleus

By similarity.

Sequence similarities: Contains 2 PDZ (DHR) domains.

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