ARTS1 / ERAP1, Polyclonal Antibody

Anti-ARTS1 / ERAP1 Antibody (Internal) IHC-plus; ERAP1; A-LAP; ALAP; APPILS; ARTS1; ERAAP; ERAAP1; KIAA0525; PILS-AP; Aminopeptidase PILS; ARTS-1; PILSAP; Human ARTS1; ERAP1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Human ERAP1 / ARTS1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Immunoaffinity Purified

PBS, 0.1% sodium azide.

1 mg/ml (lot specific)

Long term: -70 degree C; Short term: +4 degree C

Small volumes of anti-ARTS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

ARTS1/Adipocyte-derived leucine aminopeptidase (A-LAP) is a member of the M1 family of zinc metallopeptidases. A-LAP is upregulatable by gamma interferon and trims N-terminal lysine, leucine, tyrosine and asparagines residues when they are not followed by proline in the ER to yield the optimal octamer, primarily and nonamer peptides for antigen presentation by major histocompatibility complex (MHC) molecules.

Subfamily:-Metallopeptidase-M1">Family: Exopeptidase
Subfamily: Metallopeptidase M1

Immunohistochemistry (IHC - Paraffin)

IHC-P (10 - 15 ug/ml)

Anti-ERAP1 / ARTS1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-ERAP1 / ARTS1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

107,841 Da

endoplasmic reticulum aminopeptidase 1

endoplasmic reticulum aminopeptidase 1; aminopeptidase PILS; adipocyte-derived leucine aminopeptidase; aminopeptidase regulator of TNFR1 shedding; puromycin-insensitive leucyl-specific aminopeptidase; endoplasmic reticulum aminopeptidase 1 delta-Exon-11 isoform; endoplasmic reticulum aminopeptidase 1 delta-Exon-13 isoform; endoplasmic reticulum aminopeptidase 1 delta-Exon-14 isoform; endoplasmic reticulum aminopeptidase 1 delta-Exon-15 isoform; endoplasmic reticulum aminopeptidase associated with antigen processing; type 1 tumor necrosis factor receptor shedding aminopeptidase regulator

Endoplasmic reticulum aminopeptidase 1

APPILS; ARTS1; KIAA0525; A-LAP; PILS-AP  [Similar Products]

ERAP1_HUMAN

The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

ARTS1: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. Belongs to the peptidase M1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.11.-; Protease; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q15

Cellular Component: extracellular space; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; endoplasmic reticulum lumen; extracellular region; integral to membrane; cytosol

Molecular Function: protein binding; interleukin-6 receptor binding; metalloexopeptidase activity; zinc ion binding; interleukin-1, Type II receptor binding; aminopeptidase activity

Biological Process: fat cell differentiation; antigen processing and presentation of peptide antigen via MHC class I; positive regulation of angiogenesis; response to bacterium; regulation of blood pressure; membrane protein ectodomain proteolysis; angiogenesis; antigen processing and presentation of endogenous peptide antigen via MHC class I; regulation of innate immune response

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