Full Product Name
ACSF3, ID (ACSF3, Acyl-CoA synthetase family member 3, mitochondrial)
Product Synonym Names
Anti -ACSF3, ID (ACSF3, Acyl-CoA synthetase family member 3, mitochondrial)
Product Gene Name
anti-ACSF3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 16; NC_000016.9 (89160217..89222171). Location: 16q24.3
3D Structure
ModBase 3D Structure for Q4G176
Species Reactivity
Human, Mouse
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Immunogen
ACSF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 420-450 amino acids from the Central region of human ACSF3.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-ACSF3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-ACSF3 antibody
Antibodies; Abs to Mitochondrial Proteins
Applications Tested/Suitable for anti-ACSF3 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ACSF3 antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100
NCBI/Uniprot data below describe general gene information for ACSF3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_777577.2
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NCBI GenBank Nucleotide #
NM_174917.4
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UniProt Primary Accession #
Q4G176
[Other Products]
UniProt Secondary Accession #
Q6INA0; Q8N2F7; A8K4J8; C9JQL6[Other Products]
UniProt Related Accession #
Q4G176[Other Products]
Molecular Weight
64,130 Da[Similar Products]
NCBI Official Full Name
acyl-CoA synthetase family member 3, mitochondrial isoform 1
NCBI Official Synonym Full Names
acyl-CoA synthetase family member 3
NCBI Official Symbol
ACSF3 [Similar Products]
NCBI Protein Information
acyl-CoA synthetase family member 3, mitochondrial; malonyl-CoA synthetase
UniProt Protein Name
Acyl-CoA synthetase family member 3, mitochondrial
Protein Family
Acyl-CoA synthetase family
UniProt Gene Name
ACSF3 [Similar Products]
UniProt Entry Name
ACSF3_HUMAN
NCBI Summary for ACSF3
This gene encodes a member of the acyl-CoA synthetase family of enzymes that activate fatty acids by catalyzing the formation of a thioester linkage between fatty acids and coenzyme A. The encoded protein is localized to mitochondria, has high specificity for malonate and methylmalonate and possesses malonyl-CoA synthetase activity. Mutations in this gene are a cause of combined malonic and methylmalonic aciduria. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Sep 2013]
UniProt Comments for ACSF3
Function: Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates. Ref.6 Ref.8
Subcellular location: Mitochondrion Ref.8.
Involvement in disease: Combined malonic and methylmalonic aciduria (CMAMMA) [MIM:614265]: A metabolic disease characterized by malonic and methylmalonic aciduria, with urinary excretion of much larger amounts of methylmalonic acid than malonic acid, in the presence of normal malonyl-CoA decarboxylase activity. Clinical features include coma, ketoacidosis, hypoglycemia, failure to thrive, microcephaly, dystonia, axial hypotonia and/or developmental delay, and neurologic manifestations including seizures, psychiatric disease and/or cognitive decline.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8
Sequence similarities: Belongs to the ATP-dependent AMP-binding enzyme family.
Sequence caution: The sequence AAH72391.1 differs from that shown. Reason: Aberrant splicing.
Research Articles on ACSF3
1. ACSF3 was significantly upregulated, and was involved in fatty acid and lipid metabolism and accelerated liver injury in alcoholic liver disease.
Precautions
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Disclaimer
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