Full Product Name
FCRL3 Polyclonal Antibody
Product Synonym Names
FCRH3; IFGP3; IRTA3; SPAP2; CD307c
Product Gene Name
anti-FCRL3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q96P31
Immunogen
Recombinant protein of human FCRL3
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-FCRL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FCRL3 antibody
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants.
Applications Tested/Suitable for anti-FCRL3 antibody
Western Blot (WB)
Application Notes for anti-FCRL3 antibody
WB: 1:500 - 1:2000
NCBI/Uniprot data below describe general gene information for FCRL3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001307262.1
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NCBI GenBank Nucleotide #
NM_001320333.1
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UniProt Primary Accession #
Q96P31
[Other Products]
UniProt Secondary Accession #
Q5VXZ8; Q8N6S2; Q96LA4; Q96P27; Q96P28; Q96P29; Q96P30; A0N0M4; A8MTH7; D3DVD2[Other Products]
UniProt Related Accession #
Q96P31[Other Products]
NCBI Official Full Name
Fc receptor-like protein 3 isoform 3
NCBI Official Synonym Full Names
Fc receptor like 3
NCBI Official Symbol
FCRL3 [Similar Products]
NCBI Official Synonym Symbols
FCRH3; IFGP3; IRTA3; SPAP2; CD307c
[Similar Products]
NCBI Protein Information
Fc receptor-like protein 3
UniProt Protein Name
Fc receptor-like protein 3
UniProt Synonym Protein Names
Fc receptor homolog 3; FcRH3; IFGP family protein 3; hIFGP3; Immune receptor translocation-associated protein 3; SH2 domain-containing phosphatase anchor protein 2; CD_antigen: CD307c
Protein Family
Fc receptor-like protein
UniProt Gene Name
FCRL3 [Similar Products]
UniProt Synonym Gene Names
FCRH3; IFGP3; IRTA3; SPAP2; FcR-like protein 3; FcRL3; FcRH3; hIFGP3 [Similar Products]
NCBI Summary for FCRL3
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
UniProt Comments for FCRL3
FCRL3: Genetic variation in FCRL3 may be a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Genetic variation in FCRL3 may influence susceptibility to autoimmune disorders, including Graves disease. Graves disease is an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q23.1
Research Articles on FCRL3
1. The expression of Sezary signature genes: FCRL3, Tox, and miR-214, was significantly higher in samples from Sezary syndrome patients with CD164 expressing CD4(+) T cells.
Precautions
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Disclaimer
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