Product Name
CLCN2, Blocking Peptide
Full Product Name
CLCN2 Peptide - middle region
Product Gene Name
CLCN2 blocking peptide
[Similar Products]
Product Synonym Gene Name
CLC2; ECA2; ECA3; EGI3; EGMA; EJM6; EJM8; CIC-2; EGI11; LKPAT; clC-2[Similar Products]
CLCN2 peptide (MBS3247208) is used for blocking the activity of CLCN2 antibody (MBS3222540)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
Synthetic peptide located within the following region: NAVAQSLQPS LYDSIIRIKK LPYLPELGWG RHQQYRVRVE DIMVRDVPHV
3D Structure
ModBase 3D Structure for P51788
Form/Format
Lyophilized powder
Preparation and Storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of CLCN2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CLCN2 blocking peptide
This is a synthetic peptide designed for use in combination with anti- CLCN2 Antibody, made
Target Description: This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene.
Product Categories/Family for CLCN2 blocking peptide
Peptide
NCBI/Uniprot data below describe general gene information for CLCN2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001164558.1
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NCBI GenBank Nucleotide #
NM_001171087.2
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UniProt Primary Accession #
P51788
[Other Products]
UniProt Related Accession #
P51788[Other Products]
NCBI Official Full Name
chloride channel protein 2 isoform 2
NCBI Official Synonym Full Names
chloride voltage-gated channel 2
NCBI Official Symbol
CLCN2 [Similar Products]
NCBI Official Synonym Symbols
CLC2; ECA2; ECA3; EGI3; EGMA; EJM6; EJM8; CIC-2; EGI11; HALD2; LKPAT; clC-2
[Similar Products]
NCBI Protein Information
chloride channel protein 2
UniProt Protein Name
Chloride channel protein 2
Protein Family
Chloride channel protein
UniProt Gene Name
CLCN2 [Similar Products]
UniProt Synonym Gene Names
ClC-2 [Similar Products]
UniProt Entry Name
CLCN2_HUMAN
NCBI Summary for CLCN2
This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
UniProt Comments for CLCN2
CLCN2: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. Defects in CLCN2 are associated with susceptibility to epilepsy, idiopathic generalized type 11 (EIG11). A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. Defects in CLCN2 are associated with juvenile absence epilepsy type 2 (JAE2). JAE is a subtype of idiopathic generalized epilepsy (IGE) characterized by onset occurring around puberty, absence seizures, generalized tonic- clonic seizures (GTCS), GTCS on awakening and myoclonic seizures. Defects in CLCN2 are associated with juvenile myoclonic epilepsy type 8 (EJM8). A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, chloride; Transporter, ion channel; Membrane protein, integral; Membrane protein, multi-pass; Transporter
Chromosomal Location of Human Ortholog: 3q27.1
Cellular Component: plasma membrane
Molecular Function: voltage-gated chloride channel activity
Biological Process: retina development in camera-type eye; transport; transmembrane transport
Disease: Epilepsy, Idiopathic Generalized, Susceptibility To, 11; Leukoencephalopathy With Ataxia
Research Articles on CLCN2
1. The inhibitory effects of ClC-2 knockout on HBVSMC proliferation and motility were associated with inactivation of the Wnt/beta-catenin signaling pathway, as evidenced by inhibition of beta-catenin phosphorylation and nuclear translocation, and decrease of GSK-3beta phosphorylation and survivin and cyclin D1 expression.
Precautions
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Disclaimer
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