Full Product Name
BSND Polyclonal Antibody
Product Synonym Names
BART; DFNB73
Product Gene Name
anti-BSND antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purification
Immunogen
Recombinant protein of human BSND
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-49609 / sc-49607 / sc-49611
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-BSND antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-BSND antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-BSND antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
Western Blot (WB) of anti-BSND antibody
Western blot analysis of extracts of various cells, using BSND antibody.
Immunohistochemistry (IHC) of anti-BSND antibody
Immunohistochemistry of paraffin-embedded rat kidney using BSND antibody at dilution of1:100 (x40 lens).
NCBI/Uniprot data below describe general gene information for BSND. It may not necessarily be applicable to this product.
NCBI GenBank Nucleotide #
NM_057176.2
[Other Products]
UniProt Secondary Accession #
Q6NT28[Other Products]
UniProt Related Accession #
Q8WZ55[Other Products]
NCBI Official Full Name
barttin
NCBI Official Synonym Full Names
barttin CLCNK type accessory beta subunit
NCBI Official Symbol
BSND [Similar Products]
NCBI Official Synonym Symbols
BART; DFNB73
[Similar Products]
NCBI Protein Information
barttin
UniProt Protein Name
Barttin
UniProt Gene Name
BSND [Similar Products]
UniProt Synonym Gene Names
BART [Similar Products]
UniProt Entry Name
BSND_HUMAN
NCBI Summary for BSND
This gene encodes an essential beta subunit for CLC chloride channels. These heteromeric channels localize to basolateral membranes of renal tubules and of potassium-secreting epithelia of the inner ear. Mutations in this gene have been associated with Bartter syndrome with sensorineural deafness. [provided by RefSeq, Jul 2008]
UniProt Comments for BSND
BSND: Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter. Defects in BSND are the cause of Bartter syndrome type 4A (BS4A); also known as infantile Bartter syndrome with sensorineural deafness. BS refers to a group of autosomal recessive disorders characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BS4A is associated with sensorineural deafness.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 1p32.1
Cellular Component: basolateral plasma membrane; integral to plasma membrane; plasma membrane; protein complex
Molecular Function: chloride channel activity; voltage-gated chloride channel activity
Disease: Bartter Syndrome, Type 4a
Research Articles on BSND
1. results demonstrate that the carboxyl terminus of hClC-Kb is not part of the for barttin, but functionally modifies the interplay with barttin.
Precautions
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Disclaimer
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