SCN5A, Polyclonal Antibody

Goat Anti-SCN5A (aa1021-1034) Antibody; SCN5A; CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; ICCD; HH1; IVF; LQT3; SSS1; PFHB1; SSS1; sodium channel, voltage-gated, type V, alpha subunit; Nav1.5; sodium channel, voltage-gated, type V, alpha (long QT syndrome 3); cardiac sodium channel alpha subunit; sod; SCN5A antibody; CDCD2 antibody; CMD1E antibody; CMPD2 antibody; HB1 antibody; HB2 antibody; HBBD antibody; ICCD antibody; HH1 antibody; IVF antibody; LQT3 antibody; SSS1 antibody; PFHB1 antibody; SSS1 antibody; sodium channel; voltage-gated; type V; alpha subunit antibody; Nav1.5 antibody; sodium channel; voltage-gated; type V; alpha (long QT syndrome 3) antibody; cardiac sodium channel alpha subunit antibody; sodium channel; voltage-gated; type V; alpha polypeptide (long (electrocardiographic) QT syndrome 3) antibody; VF1 antibody; cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit antibody; sodium channel protein type V alpha subunit antibody; voltage-gated sodium channel type V alpha antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Goat

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul (lot specific)

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Manufactured in an ISO 9001:2008 Certified Laboratory.

Small volumes of anti-SCN5A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Peptide ELISA (EIA)

Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Preliminary experiments in lysates of Human Breast and Heart tissues gave no specific signal but low background (at antibody concentration up to 1ug/ml).

224,917 Da

sodium voltage-gated channel alpha subunit 5

sodium channel protein type 5 subunit alpha

Sodium channel protein type 5 subunit alpha

SCN5A_HUMAN

The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

SCN5A: an integral membrane protein and a voltage-gated sodium channel subunit. Mediates the voltage-dependent sodium ion permeability of excitable membranes. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. Intracellular calcium levels regulate channel inactivation. Interacts with the PDZ domain of the syntrophin SNTA1, SNTB1 and SNTB2. Interacts with NEDD4, NEDD4L, WWP2 and GPD1L. Defects in this protein are a cause of long QT syndrome type 3 (LQT3). Belongs to the sodium channel (TC 1.A.1.10) family, Nav1.5/SCN5A subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, sodium; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: caveola; cell surface; endoplasmic reticulum; integral to membrane; intracellular; lateral plasma membrane; plasma membrane; sarcolemma; T-tubule; voltage-gated sodium channel complex; Z disc

Molecular Function: ankyrin binding; calmodulin binding; enzyme binding; fibroblast growth factor binding; nitric-oxide synthase binding; protein binding; protein domain specific binding; protein kinase binding; ubiquitin protein ligase binding; voltage-gated sodium channel activity

Biological Process: cardiac muscle contraction; cerebellum development; generation of action potential; membrane depolarization; odontogenesis of dentine-containing teeth; positive regulation of action potential; positive regulation of epithelial cell proliferation; regulation of heart rate; regulation of postsynaptic membrane potential; response to denervation involved in regulation of muscle adaptation; sodium ion transport; telencephalon development

Disease: Atrial Fibrillation, Familial, 10; Brugada Syndrome 1; Cardiomyopathy, Dilated, 1e; Long Qt Syndrome 3; Progressive Familial Heart Block, Type Ia; Sick Sinus Syndrome 1, Autosomal Recessive; Sudden Infant Death Syndrome; Ventricular Fibrillation During Myocardial Infarction, Susceptibility To

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