Full Product Name
KCNE3 Antibody, Biotin conjugated
Product Synonym Names
Potassium voltage-gated channel subfamily E member 3; MinK-related peptide 2; Minimum potassium ion channel-related peptide 2; Potassium channel subunit beta MiRP2; KCNE3
Product Gene Name
anti-KCNE3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9Y6H6
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Potassium voltage-gated channel subfamily E member 3 protein (1-57AA)
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-KCNE3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KCNE3 antibody
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:12954870). Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship.
Product Categories/Family for anti-KCNE3 antibody
Neuroscience
Applications Tested/Suitable for anti-KCNE3 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for KCNE3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005463.1
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NCBI GenBank Nucleotide #
NM_005472.4
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UniProt Primary Accession #
Q9Y6H6
[Other Products]
UniProt Related Accession #
Q9Y6H6[Other Products]
Molecular Weight
11,710 Da
NCBI Official Full Name
potassium voltage-gated channel subfamily E member 3
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily E regulatory subunit 3
NCBI Official Symbol
KCNE3 [Similar Products]
NCBI Official Synonym Symbols
HYPP; HOKPP; MiRP2
[Similar Products]
NCBI Protein Information
potassium voltage-gated channel subfamily E member 3
UniProt Protein Name
Potassium voltage-gated channel subfamily E member 3
UniProt Synonym Protein Names
MinK-related peptide 2; Minimum potassium ion channel-related peptide 2; Potassium channel subunit beta MiRP2
Protein Family
Potassium voltage-gated channel subfamily
UniProt Gene Name
KCNE3 [Similar Products]
NCBI Summary for KCNE3
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. A missense mutation in this gene is associated with hypokalemic periodic paralysis. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNE3
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:12954870). Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship.
Research Articles on KCNE3
1. Structural, computational, biochemical, and electrophysiological studies lead to an atomically explicit integrative structural model of the KCNE3-KCNQ1 complex that explains how KCNE3 induces the constitutive activation of KCNQ1 channel activity, a crucial component in K(+) recycling.
Precautions
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