Product Name
CEP152, Polyclonal Antibody
Full Product Name
CEP152 Polyclonal Antibody
Product Synonym Names
CEP152; KIAA0912; Centrosomal protein of 152 kDa; Cep152
Product Gene Name
anti-CEP152 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse
Purity/Purification
Antigen Affinity Purified
Concentration
1 mg/ml (lot specific)
Immunogen
Synthesized peptide derived from the Internal region of human CEP152.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CEP152 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CEP152 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-CEP152 antibody
WB: 1:500-1:2000, IHC: 1:50-1:200, ELISA: 1:5000-1:20000
Western Blot (WB) of anti-CEP152 antibody
Western Blot analysis of HuvEc cells with CEP152 Polyclonal Antibody.
NCBI/Uniprot data below describe general gene information for CEP152. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001181927.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001194998.1
[Other Products]
UniProt Secondary Accession #
Q17RV1; Q6NTA0; E7ER66[Other Products]
UniProt Related Accession #
O94986[Other Products]
Molecular Weight
Calculated MW: 147
Observed MW: 140
NCBI Official Full Name
centrosomal protein of 152 kDa isoform 1
NCBI Official Synonym Full Names
centrosomal protein 152kDa
NCBI Official Symbol
CEP152 [Similar Products]
NCBI Official Synonym Symbols
MCPH4; MCPH9; SCKL5
[Similar Products]
NCBI Protein Information
centrosomal protein of 152 kDa
UniProt Protein Name
Centrosomal protein of 152 kDa
Protein Family
Centrosomal protein
UniProt Gene Name
CEP152 [Similar Products]
UniProt Synonym Gene Names
KIAA0912; Cep152 [Similar Products]
UniProt Entry Name
CE152_HUMAN
NCBI Summary for CEP152
This gene encodes a protein that is thought to be involved with centrosome function. Mutations in this gene have been associated with primary microcephaly (MCPH4). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]
UniProt Comments for CEP152
Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation (PubMed:21059844, PubMed:20852615). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615).
Research Articles on CEP152
1. Plk4 is intricately regulated in time and space through ordered interactions with two distinct scaffolds, Cep192 and Cep152, and a failure in this process may lead to human cancer.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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