Full Product Name
MCFD2 Antibody
Product Synonym Names
F5F8D; SDNSF; F5F8D2; LMAN1IP
Product Gene Name
anti-MCFD2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8NI22
Species Reactivity
Human, Mouse, Rat
Specificity
The antibody detects endogenous levels of total MCFD2 protein.
Purity/Purification
Antigen affinity purification
Form/Format
pH 7.4 PBS, 0.05% NaN3, 40% Glycerol
Concentration
0.7 mg/mL (lot specific)
Immunogen
Fusion protein of human MCFD2
Preparation and Storage
Store at -20 degree C.
Other Notes
Small volumes of anti-MCFD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MCFD2 antibody
This gene encodes a soluble luminal protein with two calmodulin-like EF-hand motifs at its C-terminus. This protein forms a complex with LMAN1 (lectin mannose binding protein 1; also known as ERGIC-53) that facilitates the transport of coagulation factors V (FV) and VIII (FVIII) from the endoplasmic reticulum to the Golgi apparatus via an endoplasmic reticulum Golgi intermediate compartment (ERGIC). Mutations in this gene cause combined deficiency of FV and FVIII (F5F8D); a rare autosomal recessive bleeding disorder characterized by mild to moderate bleeding and coordinate reduction in plasma FV and FVIII levels. This protein has also been shown to maintain stem cell potential in ***** central nervous system and is a marker for testicular germ cell tumors. The 3' UTR of this gene contains a transposon-like human repeat element named 'THE 1'. A processed RNA pseudogene of this gene is on chromosome 6p22.1. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Product Categories/Family for anti-MCFD2 antibody
Total protein Ab
Applications Tested/Suitable for anti-MCFD2 antibody
Immunohistochemistry (IHC)
Application Notes for anti-MCFD2 antibody
IHC: 1:20-100
Immunohistochemistry (IHC) of anti-MCFD2 antibody
The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using 47337(MCFD2 Antibody) at dilution 1/40.(Original magnification: 200)
NCBI/Uniprot data below describe general gene information for MCFD2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001164977.1
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NCBI GenBank Nucleotide #
NM_001171506.2
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UniProt Primary Accession #
Q8NI22
[Other Products]
UniProt Secondary Accession #
Q53SS3; Q68D61; Q8N3M5; A8K7W2; D6W5A9; E9PD95[Other Products]
UniProt Related Accession #
Q8NI22[Other Products]
Molecular Weight
10,718 Da
NCBI Official Full Name
multiple coagulation factor deficiency protein 2 isoform A
NCBI Official Synonym Full Names
multiple coagulation factor deficiency 2
NCBI Official Symbol
MCFD2 [Similar Products]
NCBI Official Synonym Symbols
F5F8D; SDNSF; F5F8D2; LMAN1IP
[Similar Products]
NCBI Protein Information
multiple coagulation factor deficiency protein 2
UniProt Protein Name
Multiple coagulation factor deficiency protein 2
UniProt Synonym Protein Names
Neural stem cell-derived neuronal survival protein
Protein Family
Multiple coagulation factor deficiency protein
UniProt Gene Name
MCFD2 [Similar Products]
UniProt Synonym Gene Names
SDNSF [Similar Products]
NCBI Summary for MCFD2
This gene encodes a soluble luminal protein with two calmodulin-like EF-hand motifs at its C-terminus. This protein forms a complex with LMAN1 (lectin mannose binding protein 1; also known as ERGIC-53) that facilitates the transport of coagulation factors V (FV) and VIII (FVIII) from the endoplasmic reticulum to the Golgi apparatus via an endoplasmic reticulum Golgi intermediate compartment (ERGIC). Mutations in this gene cause combined deficiency of FV and FVIII (F5F8D); a rare autosomal recessive bleeding disorder characterized by mild to moderate bleeding and coordinate reduction in plasma FV and FVIII levels. This protein has also been shown to maintain stem cell potential in ***** central nervous system and is a marker for testicular germ cell tumors. The 3' UTR of this gene contains a transposon-like human repeat element named 'THE 1'. A processed RNA pseudogene of this gene is on chromosome 6p22.1. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2016]
UniProt Comments for MCFD2
The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors.
Research Articles on MCFD2
1. Combined deficiency of factors V and VIII by chance coinheritance of parahaemophilia and haemophilia A, but not by mutations of either LMAN1 or MCFD2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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