Product Name
(Rhesus macaque) CD40 ligand (CD40LG), Recombinant Protein
Popular Item
Full Product Name
Recombinant Macaca mulatta (Rhesus macaque) CD40 ligand (CD40LG)
Product Synonym Names
CD40 ligand; CD40-L; Tumor necrosis factor ligand superfamily member 5; CD_antigen=; CD154Cleaved into the following 2 chains:; 1. CD40 ligand, membrane form; 2. CD40 ligand, soluble form
Product Gene Name
CD40LG recombinant protein
[Similar Products]
Product Synonym Gene Name
CD40LG; CD40L; TNFSF5[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
44-261aa; Extracellular Domain
Sequence
VYLHRRLDKI EDERNLHEDF VFMKTIQRCN TGERSLSLLN CEEIKSQFEG FVKDIMLNKE EKKKENSFEM QKGDQNPQIA AHVISEASSK TTSVLQWAEK GYYTMSNNLV TLENGKQLTV KRQGLYYIYA QVTFCSNREA SSQAPFIASL CLKSPGRFER ILLRAANTHS SAKPCGQQSI HLGGVFELQP GASVFVNVTD PSQVSHGTGF TSFGLLKL
3D Structure
ModBase 3D Structure for P63304
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Macaca mulatta (Rhesus macaque)
Production Note
Special Offer: The E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CD40LG recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CD40LG recombinant protein
Cytokine that binds to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching.
Product Categories/Family for CD40LG recombinant protein
Immunology
NCBI/Uniprot data below describe general gene information for CD40LG. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001028011.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001032839.1
[Other Products]
UniProt Primary Accession #
P63304
[Other Products]
UniProt Secondary Accession #
Q9BDC7[Other Products]
UniProt Related Accession #
P63304[Other Products]
Molecular Weight
29,366 Da
NCBI Official Full Name
CD40 ligand
NCBI Official Symbol
CD40LG [Similar Products]
NCBI Protein Information
CD40 ligand; CD40-L; CD154 protein; tumor necrosis factor ligand superfamily member 5; CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome)
UniProt Protein Name
CD40 ligand
UniProt Synonym Protein Names
Tumor necrosis factor ligand superfamily member 5; CD_antigen: CD154Cleaved into the following 2 chains:CD40 ligand, membrane form; CD40 ligand, soluble form
Protein Family
CD40 ligand
UniProt Gene Name
CD40LG [Similar Products]
UniProt Synonym Gene Names
CD40L; TNFSF5; CD40-L [Similar Products]
UniProt Entry Name
CD40L_MACMU
UniProt Comments for CD40LG
Cytokine that binds to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching.
Research Articles on CD40LG
1. Both two-trimer and four-trimer forms of macaque CD40L were active in B-cell proliferation assays using macaque and human cells.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
