Product Name
43 kDa receptor-associated protein of the synapse (Rapsn), Recombinant Protein
Full Product Name
Recombinant Mouse 43 kDa receptor-associated protein of the synapse (Rapsn)
Product Gene Name
Rapsn recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
2-412aa, Full Length of Mature Protein
Sequence
GQDQTKQQIE KGLQLYQSNQ TEKALQVWMK VLEKGSDLVG RFRVLGCLVT AHSEMGRYKE MLKFAVVQID TARGLEDADF LLESYLNLAR SNEKLCEFHK TISYCKTCLG LPGTRAGAQL GGQVSLSMGN AFLGLSLFQK ALESFEKALR YAHNNDDTML ECRVCCSLGS FYAQVKDYEK ALFFPCKAAE LVNDYGKGWS LKYRAMSQYH MAVAYRLLGH LGSAMECCEE SMKIALQHGD RPLQALCLLC FADIHRSRGD LETAFPRYDS AMSIMTEIGN RLGQVHVLLG VAKCWMARKV QDKALDAIEK AQDLAEEVGN KLSQLKLHCL SESIYRSKGL QRELRTHVVR FHECVEETEL YCGLCGESIG ERNSRLQALP CSHIFHLRCL QNNGTRSCPN CRRSSMKPGF V
3D Structure
ModBase 3D Structure for P12672
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Rapsn recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Rapsn recombinant protein
This protein belongs to a family of proteins that are receptor associated proteins of the synapse. It contains a conserved cAMP-dependent protein kinase phosphorylation site. It is believed to play some role in anchoring or stabilizing the nicotinic acetylcholine receptor at synaptic sites. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin. Two splice variants have been identified for this gene.
NCBI/Uniprot data below describe general gene information for Rapsn. It may not necessarily be applicable to this product.
NCBI Accession #
NP_033049.2
[Other Products]
NCBI GenBank Nucleotide #
NM_009023.3
[Other Products]
UniProt Primary Accession #
P12672
[Other Products]
UniProt Secondary Accession #
Q2M2N6[Other Products]
UniProt Related Accession #
P12672[Other Products]
Molecular Weight
46,393 Da
NCBI Official Full Name
43 kDa receptor-associated protein of the synapse
NCBI Official Synonym Full Names
receptor-associated protein of the synapse
NCBI Official Symbol
Rapsn [Similar Products]
NCBI Official Synonym Symbols
Raps; 43kDa; Nraps; rapsyn
[Similar Products]
NCBI Protein Information
43 kDa receptor-associated protein of the synapse
UniProt Protein Name
43 kDa receptor-associated protein of the synapse
UniProt Synonym Protein Names
43 kDa postsynaptic protein; Acetylcholine receptor-associated 43 kDa protein
Protein Family
43 kDa receptor-associated protein of the synapse
UniProt Gene Name
Rapsn [Similar Products]
UniProt Synonym Gene Names
RAPsyn [Similar Products]
UniProt Comments for Rapsn
Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin ().
Research Articles on Rapsn
1. The RING domain of rapsyn contains E3 ligase activity. Mutation of the RING domain that abolishes the enzyme activity inhibits rapsyn- as well as agrin-induced AChR clustering in heterologous and muscle cells. Further
biological and genetic studies support a working model where rapsyn, a classic scaffold protein, serves as an E3 ligase to induce AChR clustering and NMJ formation, possibly by regulation of AChR neddylation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
