Product Name
MYO7A, Blocking Peptide
Full Product Name
MYO7A Blocking Peptide
Product Synonym Names
USH1B; Unconventional myosin-VIIa
Product Gene Name
MYO7A blocking peptide
[Similar Products]
MYO7A peptide (MBS823432) is used for blocking the activity of MYO7A antibody (MBS821898)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q13402
Species Reactivity
Human, Mouse, Rat, Pig
Form/Format
Lyophilized powder
Quality Control
The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Other Notes
Small volumes of MYO7A blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
MYO7A blocking peptide
The peptide is used to block Anti-MYO7A Antibody reactivity.
Applications Tested/Suitable for MYO7A blocking peptide
Blocking (BL)
Application Notes for MYO7A blocking peptide
Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
NCBI/Uniprot data below describe general gene information for MYO7A. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000251.3
[Other Products]
NCBI GenBank Nucleotide #
NM_000260.3
[Other Products]
UniProt Primary Accession #
Q13402
[Other Products]
UniProt Secondary Accession #
P78427; Q13321; Q14785; Q92821; Q92822; B9A011; F8VUN5[Other Products]
UniProt Related Accession #
Q13402[Other Products]
Molecular Weight
249,165 Da
NCBI Official Full Name
unconventional myosin-VIIa isoform 1
NCBI Official Synonym Full Names
myosin VIIA
NCBI Official Symbol
MYO7A [Similar Products]
NCBI Official Synonym Symbols
DFNB2; MYU7A; NSRD2; USH1B; DFNA11; MYOVIIA
[Similar Products]
NCBI Protein Information
unconventional myosin-VIIa; myosin VIIA (Usher syndrome 1B (autosomal recessive, severe))
UniProt Protein Name
Unconventional myosin-VIIa
Protein Family
Unconventional myosin
UniProt Gene Name
MYO7A [Similar Products]
UniProt Synonym Gene Names
USH1B [Similar Products]
UniProt Entry Name
MYO7A_HUMAN
NCBI Summary for MYO7A
This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
UniProt Comments for MYO7A
MYO7A: an actin-based motor molecule with ATPase activity and a calcium sensitive calmodulin binding subunit. May play a role in trafficking of ribbon- synaptic vesicle complexes and renewal of outer photoreceptor disks. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity. Seven alternatively spliced isoforms have been described.
Protein type: Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 11q13.5
Cellular Component: stereocilium; photoreceptor outer segment; photoreceptor inner segment; lysosomal membrane; apical plasma membrane; cytoplasm; melanosome; synapse; cell cortex; cytosol; photoreceptor connecting cilium
Molecular Function: calmodulin binding; actin filament binding; microfilament motor activity; protein domain specific binding; protein binding; protein homodimerization activity; spectrin binding; actin-dependent ATPase activity; ADP binding; ATP binding
Biological Process: phagolysosome formation; intracellular protein transport; eye photoreceptor cell development; sensory perception of sound; pigment granule transport; visual perception; actin filament-based movement; metabolic process; lysosome organization and biogenesis; sensory perception of light stimulus; auditory receptor cell stereocilium organization and biogenesis; equilibrioception; post-embryonic organ morphogenesis
Disease: Deafness, Autosomal Recessive 2; Deafness, Autosomal Dominant 11; Usher Syndrome, Type I
Research Articles on MYO7A
1. The MYO7A gene is responsible for two distinct diseases and gives evidence that the p.P1887L mutation in a homozygous state may be responsible for nonsyndromic hearing loss.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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