Product Name
A Disintegrin And Metalloproteinase With Thrombospondin 7 (ADAMTS7), Polyclonal Antibody
Full Product Name
HRP-Linked Polyclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 7 (ADAMTS7)
Product Synonym Names
COMPase
Product Gene Name
anti-ADAMTS7 antibody
[Similar Products]
Matching Pairs
Unconjugated Antibody: A Disintegrin And Metalloproteinase With Thrombospondin 7 (ADAMTS7) (MBS2004392)
HRP Conjugated Antibody: A Disintegrin And Metalloproteinase With Thrombospondin 7 (ADAMTS7) (MBS2061371)
Matching Pairs
HRP Conjugated Antibody: A Disintegrin And Metalloproteinase With Thrombospondin 7 (ADAMTS7) (MBS2061371)
Immunogen: A Disintegrin And Metalloproteinase With Thrombospondin 7 (ADAMTS7) (MBS2010788)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UKP4
Concentration
200ug/ml (lot specific)
Immunogen
ADAMTS7 (Val1589~Arg1686)
Unconjugated Antibody
The unconjugated antibody version of this item is also available as catalog #MBS2004392
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customerâs specifications, please inquire.
Other Notes
Small volumes of anti-ADAMTS7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ADAMTS7 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
NCBI/Uniprot data below describe general gene information for ADAMTS7. It may not necessarily be applicable to this product.
NCBI Accession #
NP_055087.2
[Other Products]
NCBI GenBank Nucleotide #
NM_014272.4
[Other Products]
UniProt Primary Accession #
Q9UKP4
[Other Products]
UniProt Secondary Accession #
Q14F51; Q6P7J9[Other Products]
UniProt Related Accession #
Q9UKP4[Other Products]
Molecular Weight
184,095 Da
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 7 preproprotein
NCBI Official Synonym Full Names
ADAM metallopeptidase with thrombospondin type 1 motif 7
NCBI Official Symbol
ADAMTS7 [Similar Products]
NCBI Official Synonym Symbols
ADAM-TS7; ADAMTS-7; ADAM-TS 7
[Similar Products]
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 7
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 7
UniProt Synonym Protein Names
COMPase
Protein Family
A disintegrin and metalloproteinase with thrombospondin motifs
UniProt Gene Name
ADAMTS7 [Similar Products]
UniProt Synonym Gene Names
ADAM-TS 7; ADAM-TS7; ADAMTS-7 [Similar Products]
NCBI Summary for ADAMTS7
The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and may regulate vascular smooth muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility to coronary artery disease. [provided by RefSeq, Feb 2016]
UniProt Comments for ADAMTS7
ADAMTS7: Metalloprotease that may play a role in the degradation of COMP.
Protein type: Cell surface; EC 3.4.24.-; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 15q25.1
Cellular Component: endoplasmic reticulum lumen
Molecular Function: metalloendopeptidase activity; metallopeptidase activity; protein binding
Biological Process: negative regulation of chondrocyte differentiation; proteolysis involved in cellular protein catabolic process
Research Articles on ADAMTS7
1. Expression of miR-26a and miR-29a was significantly down regulated in leukoplakia and cancer tissues but up regulated in lichen planus tissues. Expression of target genes such as, ADAMTS7, ATP1B1, COL4A2, CPEB3, CDK6, DNMT3a and PI3KR1 was significantly down regulated in at least two of three disease types with respect to normal tissues.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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