Product Name
NLRP7, cDNA Clone
Full Product Name
NLRP7 cDNA Clone
Product Gene Name
NLRP7 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
ATGACATCGC CCCAGCTAGA GTGGACTCTG CAGACCCTTC TGGAGCAGCT GAACGAGGAT GAATTAAAGA GTTTCAAATC CCTTTTATGG GCTTTTCCCC TCGAAGACGT GCTACAGAAG ACCCCATGGT CTGAGGTGGA AGAGGCTGAT GGCAAGAAAC TGGCAGAAAT TCTGGTCAAC ACCTCCTCAG AAAATTGGAT AAGGAATGCG ACTGTGAACA TCTTGGAAGA GATGAATCTC ACGGAATTGT GTAAGATGGC AAAGGCTGAG ATGATGGAGG ACGGACAGGT GCAAGAAATA GATAATCCTG AGCTGGGAGA TGCAGAAGAA GACTCGGAGT TAGCAAAGCC AGGTGAAAAG GAAGGATGGA GAAATTCAAT GGAGAAACAA TCTTTGGTCT GGAAGAACAC CTTTTGGCAA GGAGACATTG ACAATTTCCA TGACGACGTC ACTCTGAGAA ACCAACGGTT CATTCCATTC TTGAATCCCA GAACACCCAG GAAGCTAACA CCTTACACGG TGGTGCTGCA CGGCCCCGCA GGCGTGGGGA AAACCACGCT GGCCAAAAAG TGTATGCTGG ACTGGACAGA CTGCAACCTC AGCCCGACGC TCAGATACGC GTTCTACCTC AGCTGCAAGG AGCTCAGCCG CATGGGCCCC TGCAGTTTTG CAGAGCTGAT CTCCAAAGAC TGGCCTGAAT TGCAGGATGA CATTCCAAGC ATCCTAGCCC AAGCACAGAG AATCCTGTTC GTGGTCGATG GCCTTGATGA GCTGAAAGTC CCACCTGGGG CGCTGATCCA GGACATCTGC GGGGACTGGG AGAAGAAGAA GCCGGTGCCC GTCCTCCTGG GGAGTTTGCT GAAGAGGAAG ATGTTACCCA GGGCAGCCTT GCTGGTCACC ACGCGGCCCA GGGCACTGAG GGACCTCCGG ATCCTGGCGC AGCAGCCGAT CTACGTAAGG GTGGAGGGCT TCCTGGAGGA GGACAGGAGG GCCTATTTCC TGAGACACTT TGGAGACGAG GACCAAGCCA TGCGTGCCTT TGAGCTAATG AGGAGCAACG CGGCCCTGTT CCAGCTGGGC TCGGCCCCCG CGGTGTGCTG GATTGTGTGC ACGACTCTGA AGCTGCAGAT GGAGAAGGGG GAGGACCCGG TCCCCACCTG CCTCACCCGC ACGGGGCTGT TCCTGCGTTT CCTCTGCAGC CGGTTCCCGC AGGGCGCACA GCTGCGGGGC GCGCTGCGGA CGCTGAGCCT CCTGGCCGCG CAGGGCCTGT GGGCGCAGAT GTCCGTGTTC CACCGAGAGG ACCTGGAAAG GCTCGGGGTG CAGGAGTCCG ACCTCCGTCT GTTCCTGGAC GGAGACATCC TCCGCCAGGA CAGAGTCTCC AAAGGCTGCT ACTCCTTCAT CCACCTCAGC TTCCAGCAGT TTCTCACTGC CCTGTTCTAC ACCCTGGAGA AGGAGGAGGG GGAGGACAGG GACGGCCACG CCTGGGACAT CGGGGACGTA CAGAAGCTGC TTTCCGGAGA AGAAAGACTC AAGAACCCCG ACCTGATTCA AGTAGGACAC TTCTTATTCG GCCTCGCTAA CGAGAAGAGA GCCAAGGAGT TGGAGGCCAC TTTTGGCTGC CGGATGTCAC CGGACATCAA ACAGGAATTG CTGCAATGCA AAGCACATCT TCATGCAAAT AAGCCCTTAT CCGTGACCGA CCTGAAGGAG GTCTTGGGCT GCCTGTATGA GTCTCAGGAG GAGGAGCTGG CGAAGGTGGT GGTGGCCCCG TTCAAGGAAA TTTCTATTCA CCTGACAAAT ACTTCTGAAG TGATGCATTG TTCCTTCAGC CTGAAGCATT GTCAAGACTT GCAGAAACTC TCACTGCAGG TAGCAAAGGG GGTGTTCCTG GAGAATTACA TGGATTTTGA ACTGGACATT GAATTTGAAA GGTGCACTTA CCTAACCATT CCGAACTGGG CTCGGCAGGA TCTTCGCTCT CTTCGCCTCT GGACAGATTT CTGCTCTCTC TTCAGCTCAA ACAGCAACCT CAAGTTTCTG GAAGTGAAAC AAAGCTTCCT GAGTGACTCT TCTGTGCGGA TTCTTTGTGA CCACGTAACC CGTAGCACCT GTCATCTGCA GAAAGTGGAG ATTAAAAACG TCACCCCTGA CACCGCGTAC CGGGACTTCT GTCTTGCTTT CATTGGGAAG AAGACCCTCA CGCACCTGAC CCTGGCAGGG CACATCGAGT GGGAACGCAC GATGATGCTG ATGCTGTGTG ACCTGCTCAG AAATCATAAA TGCAACCTGC AGTACCTGAG GTTGGGAGGT CACTGTGCCA CCCCGGAGCA GTGGGCTGAA TTCTTCTATG TCCTCAAAGC CAACCAGTCC CTGAAGCACC TGCGTCTCTC AGCCAATGTG CTCCTGGATG AGGGTGCCAT GTTGCTGTAC AAGACCATGA CACGCCCAAA ACACTTCCTG CAGATGTTGT CGTTGGAAAA CTGTCGTCTT ACAGAAGCCA GTTGCAAGGA CCTTGCTGCT GTCTTGGTTG TCAGCAAGAA GCTGACACAC CTGTGCTTGG CCAAGAACCC CATTGGGGAT ACAGGGGTGA AGTTTCTGTG TGAGGGCTTG AGTTACCCTG ATTGTAAACT GCAGACCTTG GTGTTACAGC AATGCAGCAT AACCAAGCTT GGCTGTAGAT ACCTCTCAGA GGCGCTCCAA GAAGCCTGCA GCCTCACAAA CCTGGACTTG AGTATCAACC AGATAGCTCG TGGATTGTGG ATTCTCTGTC AGGCGTTAGA GAATCCAAAC TGTAACCTAA AACACCTACG CCTCTGGAGC TGCTCCCTCA TGCCTTTCTA TTGTCAGCAT CTTGGATCTG CTCTCCTCAG CAATCAGAAG CTTGAAACTC TGGACCTGGG CCAGAATCAT TTGTGGAAGA GTGGCATAAT TAAGCTCTTT GGGGTTCTAA GACAAAGAAC TGGATCCTTG AAGATACTCA GGTTGAAGAC CTATGAAACT AATTTGGAAA TCAAGAAGCT GTTGGAGGAA GTGAAAGAAA AGAATCCCAA GCTGACTATT GATTGCAATG CTTCCGGGGC AACGGCACCT CCGTGCTGTG ACTTTTTTTG CTGA
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of NLRP7 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for NLRP7. It may not necessarily be applicable to this product.
NCBI Accession #
BC109125
[Other Products]
UniProt Secondary Accession #
Q32MH8; Q7RTR1; E9PE16[Other Products]
UniProt Related Accession #
Q8WX94[Other Products]
Molecular Weight
118,303 Da
NCBI Official Full Name
Homo sapiens NLR family, pyrin domain containing 7, mRNA
NCBI Official Synonym Full Names
NLR family pyrin domain containing 7
NCBI Official Symbol
NLRP7 [Similar Products]
NCBI Official Synonym Symbols
HYDM; PAN7; NALP7; NOD12; PYPAF3; CLR19.4
[Similar Products]
NCBI Protein Information
NACHT, LRR and PYD domains-containing protein 7
UniProt Protein Name
NACHT, LRR and PYD domains-containing protein 7
UniProt Synonym Protein Names
Nucleotide-binding oligomerization domain protein 12; PYRIN-containing APAF1-like protein 3
Protein Family
NACHT, LRR and PYD domains-containing protein
UniProt Gene Name
NLRP7 [Similar Products]
UniProt Synonym Gene Names
NALP7; NOD12; PYPAF3 [Similar Products]
UniProt Entry Name
NALP7_HUMAN
NCBI Summary for NLRP7
This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for NLRP7
NLRP7: Inhibits CASP1/caspase-1-dependent IL1B secretion. Defects in NLRP7 are the cause of hydatidiform mole recurrent type 1 (HYDM1). A disorder characterized by excessive trophoblast development and the presence of a growing mass of tissue inside the uterus at the beginning of a pregnancy. It leads to abnormal pregnancies with no embryo, and cystic degeneration of the chorionic villi. Belongs to the NLRP family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 19q13.42
Disease: Hydatidiform Mole, Recurrent, 1
Research Articles on NLRP7
1. the NLRP7 inflammasome contributes to IL-1beta secretion and induction of pyroptosis in response to M. bovis infection in THP-1 macrophages.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
