Full Product Name
COX4(isoform1) Monoclonal Antibody
Product Synonym Names
cytochrome c oxidase subunit 4 isoform 2, mitochondrial COX IV-2 cytochrome c oxidase subunit IV-like 2
Product Gene Name
anti-COX4 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q96KJ9
Purity/Purification
Purified by antigen-affinity chromatography.
Form/Format
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Immunogen Description
A synthetic peptide (NPIQGLASKWDYEKNEWKKC) of human COX4(C-terminus).
Target Name
COX4(isoform1)
Preparation and Storage
store at -20 degree C
Other Notes
Small volumes of anti-COX4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-COX4 antibody
Total protein Ab
Applications Tested/Suitable for anti-COX4 antibody
Western Blot (WB), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)
Application Notes for anti-COX4 antibody
Western blotting: 1:1000
Testing Data of anti-COX4 antibody
1:4000 dilution of this antibody detected COX (C-terminus)on 20
Testing Data of anti-COX4 antibody
1:150 dilution from a previous lot detected COX4 (C-terminus) in Hela
Testing Data of anti-COX4 antibody
K562 cells stained with COX4 (red, 1:100 dilution), followed by FITC-conjugated goat anti-mouse IgG. Blue line histogram represents the isotype control, normal mouse IgG
NCBI/Uniprot data below describe general gene information for COX4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_115998.2
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NCBI GenBank Nucleotide #
NM_032609.2
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UniProt Primary Accession #
Q96KJ9
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UniProt Secondary Accession #
Q6GTF4; Q9H0Z4[Other Products]
UniProt Related Accession #
Q96KJ9[Other Products]
Molecular Weight
20,010 Da
NCBI Official Full Name
cytochrome c oxidase subunit 4 isoform 2, mitochondrial
NCBI Official Synonym Full Names
cytochrome c oxidase subunit IV isoform 2 (lung)
NCBI Official Symbol
COX4I2 [Similar Products]
NCBI Official Synonym Symbols
COX4; COX4B; COX4-2; COX4L2; COXIV-2; dJ857M17.2
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NCBI Protein Information
cytochrome c oxidase subunit 4 isoform 2, mitochondrial
UniProt Protein Name
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial
UniProt Synonym Protein Names
Cytochrome c oxidase subunit IV isoform 2; COX IV-2
UniProt Gene Name
COX4I2 [Similar Products]
UniProt Synonym Gene Names
COX4L2; COX IV-2 [Similar Products]
UniProt Entry Name
COX42_HUMAN
NCBI Summary for COX4
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation. [provided by RefSeq, Jul 2008]
UniProt Comments for COX4
COX4I2: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Defects in COX4I2 are the cause of exocrine pancreatic insufficiency dyserythropoietic anemia and calvarial hyperostosis (EPIDACH). Patients present with pancreatic insufficiency, intestinal malabsorption, failure to thrive, and anemia soon after birth. Belongs to the cytochrome c oxidase IV family.
Protein type: Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 20q11.21
Cellular Component: mitochondrial respiratory chain complex IV
Molecular Function: cytochrome-c oxidase activity
Biological Process: generation of precursor metabolites and energy; cellular respiration
Disease: Exocrine Pancreatic Insufficiency, Dyserythropoietic Anemia, And Calvarial Hyperostosis
Research Articles on COX4
1. Identification of three transcription factors that bind a conserved responsive element of the COX4I2 gene, namely recombination signal sequence-binding protein Jkappa (RBPJ), coiled-coil-helix-coiled-coil-helix domain 2 (CHCHD2) and CXXC finger protein 5 (CXXC5).
Precautions
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Disclaimer
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