Product Name
Astacin-like metalloendopeptidase (Astl), Recombinant Protein
Full Product Name
Recombinant Mouse Astacin-like metalloendopeptidase (Astl)
Product Gene Name
Astl recombinant protein
[Similar Products]
Product Synonym Gene Name
Astl[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
24-435aa, Full Length of Mature Protein
Sequence
APSASRCSGV CSTSVPEGFT PEGSPVFQDK DIPAINQGLI SEETPESSFL VEGDIIRPSP FRLLSVTNNK WPKGVGGFVE IPFLLSRKYD ELSRRVIMDA FAEFERFTCI RFVAYHGQRD FVSILPMAGC FSGVGRSGGM QVVSLAPTCL RKGRGIVLHE LMHVLGFWHE HSRADRDRYI QVNWNEILPG FEINFIKSRS TNMLVPYDYS SVMHYGRFAF SWRGQPTIIP LWTSSVHIGQ RWNLSTSDIT RVCRLYNCSR SVPDSHGRGF EAQSDGSSLT PASISRLQRL LEALSEESGS SAPSGSRTGG QSIAGLGNSQ QGWEHPPQST FSVGALARPP QMLADASKSG PGAGADSLSL EQFQLAQAPT VPLALFPEAR DKPAPIQDAF ERLAPLPGGC APGSHIREVP RD
3D Structure
ModBase 3D Structure for Q6HA09
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Astl recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Astl. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001277932.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001291003.1
[Other Products]
UniProt Primary Accession #
Q6HA09
[Other Products]
UniProt Secondary Accession #
Q8BMA1; A2AHU0; A2AHU1; G7Z016; G7Z017; G7Z018; G7Z019[Other Products]
UniProt Related Accession #
Q6HA09[Other Products]
Molecular Weight
41,388 Da
NCBI Official Full Name
astacin-like metalloendopeptidase isoform a
NCBI Official Synonym Full Names
astacin-like metalloendopeptidase (M12 family)
NCBI Official Symbol
Astl [Similar Products]
NCBI Official Synonym Symbols
Sas1b; C87576; 7420700F21
[Similar Products]
NCBI Protein Information
astacin-like metalloendopeptidase
UniProt Protein Name
Astacin-like metalloendopeptidase
UniProt Synonym Protein Names
Oocyte astacin; Ovastacin; Sperm acrosomal SLLP1-binding protein
Protein Family
Astacin-like metalloendopeptidase
UniProt Gene Name
Astl [Similar Products]
UniProt Comments for Astl
Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding.
Research Articles on Astl
1. Seven amino acid motif near Astl N-terminus is necessary and sufficient for cortical granule localization.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
