MEFV, Polyclonal Antibody

Pyrin; Marenostrin; MEFV; MEF

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This MEFV antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 418-445 amino acids from the Central region of human MEFV.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.33 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-MEFV antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a protein, also known as pyrin or
marenostrin, that is an important modulator of innate immunity.
Mutations in this gene are associated with Mediterranean fever, a
hereditary periodic fever syndrome.

Immunology; Signal Transduction

Western Blot (WB), ELISA (EIA)

WB~~1:1000

MEFV Antibody (Center) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the MEFV antibody detected the MEFV protein (arrow).

86444

Mediterranean fever

pyrin

Pyrin

MEF  [Similar Products]

MEFV_HUMAN

This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome. [provided by RefSeq, Jul 2008]

pyrin: Probably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeleton organization. Defects in MEFV are the cause of familial Mediterranean fever autosomal recessive (ARFMF). ARFMF is an inherited disorder characterized by recurrent episodic fever, serosal inflammation and pain in the abdomen, chest or joints. ARFMF is frequently complicated by amyloidosis, which leads to renal failure and can be prophylactically treated with colchicine. ARFMF primarily affects ancestral ethnic groups living around the Mediterranean basin: North African Jews, Armenians, Arabs and Turks. The disease is also distributed in other populations including Greeks, Cypriots, Italians and Spanish, although at a lower prevalence. Defects in MEFV are the cause of familial Mediterranean fever autosomal dominant (ADFMF). ADFMF is characterized by periodic fever, serosal inflammation and pain in the abdomen, chest or joints as seen also in the autosomal recessive form of the disease. It is associated with renal amyloidosis and characterized by colchicine unresponsiveness. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: ruffle; microtubule; microtubule associated complex; lamellipodium; cytosol; nucleus

Molecular Function: zinc ion binding; actin binding

Biological Process: negative regulation of interleukin-12 production; negative regulation of inflammatory response; innate immune response; negative regulation of interleukin-1 beta production; inflammatory response

Disease: Familial Mediterranean Fever; Familial Mediterranean Fever, Autosomal Dominant

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Simsek, I., et al. Clin. Rheumatol. (2010) In press :

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