CANT1, Polyclonal Antibody

Anti -CANT1 (Putative NF-kappa-B-activating Protein 107, Putative MAPK-activating Protein PM09, Apyrase Homolog, Soluble Calcium-activated Nucleotidase 1, SCAN-1, SHAPY)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 17; NC_000017.10 (76987798..77005899, complement). Location: 17q25.3

Polyclonal

IgG

Rabbit

Recognizes human CANT1. Species Crossreactivity: mouse.

Serum
Serum

Supplied as a liquid.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-CANT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

CANT1 belongs to the apyrase family. It functions as a calcium-dependent nucleotidase with a preference for UDP.

Antibodies; Abs to Enzymes, Nucleotidase

Western Blot (WB), Immunoprecipitation (IP)

Suitable for use in Western Blot and Immunoprecipitation.

44,840 Da[Similar Products]

calcium activated nucleotidase 1

soluble calcium-activated nucleotidase 1; apyrase homolog; putative MAPK-activating protein PM09; putative NF-kappa-B-activating protein 107; soluble Ca-activated nucleotidase, isozyme 1; soluble calcium-activated nucleotidase SCAN-1; Ca2+-dependent endoplasmic reticulum nucleoside diphosphatase; micromelic dwarfism with vertebral and metaphyseal abnormalities and advanced carpotarsal ossification

Soluble calcium-activated nucleotidase 1

SHAPY; SCAN-1  [Similar Products]

CANT1_HUMAN

This protein encoded by this gene belongs to the apyrase family. It functions as a calcium-dependent nucleotidase with a preference for UDP. Mutations in this gene are associated with Desbuquois dysplasia with hand anomalies. Alternatively spliced transcript variants have been noted for this gene.[provided by RefSeq, Mar 2010]

CANT1: Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis. Defects in CANT1 are the cause of Desbuquois dysplasia (DBQD). A chondrodysplasia characterized by severe prenatal and postnatal growth retardation (less than -5 SD), joint laxity, short extremities, progressive scoliosis, round face, midface hypoplasia, prominent bulging eyes. The main radiologic features are short long bones with metaphyseal splay, a 'Swedish key' appearance of the proximal femur (exaggerated trochanter), and advance carpal and tarsal bone age. Two forms of Desbuquois dysplasia are distinguished on the basis of the presence (type 1) or absence (type 2) of characteristic hand anomalies: an extra ossification center distal to the second metacarpal, delta phalanx, bifid distal thumb phalanx, and phalangeal dislocations. Belongs to the apyrase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; EC 3.6.1.6; Hydrolase; Nucleotide Metabolism - pyrimidine; Endoplasmic reticulum; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function: signal transducer activity; calcium ion binding; uridine-diphosphatase activity

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; proteoglycan biosynthetic process; signal transduction

Disease: Desbuquois Dysplasia 1

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