Full Product Name
ASIC3 Polyclonal Antibody
Product Gene Name
anti-ASIC3 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UHC3
Other Notes
Small volumes of anti-ASIC3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ASIC3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_004760.1
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NCBI GenBank Nucleotide #
NM_004769.3
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UniProt Primary Accession #
Q9UHC3
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UniProt Secondary Accession #
O60263; O75906; Q59FN9; Q9UER8; Q9UHC4; B2R9V0[Other Products]
UniProt Related Accession #
Q9UHC3[Other Products]
Molecular Weight
44,999 Da
NCBI Official Full Name
acid-sensing ion channel 3 isoform a
NCBI Official Synonym Full Names
acid sensing ion channel subunit 3
NCBI Official Symbol
ASIC3 [Similar Products]
NCBI Official Synonym Symbols
ACCN3; TNaC1; DRASIC; SLNAC1
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NCBI Protein Information
acid-sensing ion channel 3
UniProt Protein Name
Acid-sensing ion channel 3
UniProt Synonym Protein Names
Amiloride-sensitive cation channel 3; Neuronal amiloride-sensitive cation channel 3; Testis sodium channel 1; hTNaC1
Protein Family
Acid-sensing ion channel
UniProt Gene Name
ASIC3 [Similar Products]
UniProt Synonym Gene Names
ACCN3; SLNAC1; TNAC1; ASIC3; hASIC3; hTNaC1 [Similar Products]
NCBI Summary for ASIC3
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]
UniProt Comments for ASIC3
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.
Research Articles on ASIC3
1. the data demonstrate a functional link between ASICs and [Ca(2+)]i/RhoA pathway, which contributes to the acidity-induced epithelial-mesenchymal transition.
Precautions
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Disclaimer
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