GPR119, Polyclonal Antibody

Glucose-dependent insulinotropic receptor; G-protein coupled receptor 119; GPR119

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

GPR119 Antibody detects endogenous levels of total GPR119 protein.

Purified from rabbit antiserum by affinity-chromatography using immunogen.

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1 mg/ml (lot specific)

Stable at -20 degree C for at least 1 year.

Small volumes of anti-GPR119 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)

WB: 1:500~1:1000
IF: 1:100~1:500
ELISA: 1:1000

Immunofluorescence analysis of MCF7 cells, using GPR119 Antibody. The picture on the right is blocked with the synthesized peptide.

Western blot analysis of lysates from K562 cells, using GPR119 Antibody. The lane on the right is blocked with the synthesized peptide.

36 kDa

G protein-coupled receptor 119

glucose-dependent insulinotropic receptor

Glucose-dependent insulinotropic receptor

This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.[provided by RefSeq, Jan 2010]

Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.

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