Full Product Name
Mafa antibody - C-terminal region
Product Gene Name
anti-MAFA antibody
[Similar Products]
Product Synonym Gene Name
RIPE3b1[Similar Products]
Antibody/Peptide Pairs
Mafa peptide (MBS3228640) is used for blocking the activity of Mafa antibody (MBS3203673)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: KLEVGRLAKE RDLYKEKYEK LAGRGGPGGA GGAGFPREPS PAQAGPGAAK
3D Structure
ModBase 3D Structure for Q8CF90
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Human: 86%; Mouse: 100%; Rat: 100%
Immunogen
The immunogen is a synthetic peptide corresponding to a region of Mouse
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-MAFA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MAFA antibody
This is a rabbit polyclonal antibody against Mafa. It was validated on Western Blot
Target Description: Mafa acts as a transcriptional factor. Mafa specifically binds the insulin enhancer element RIPE3b. Mafa cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Mafa regulates the insulin gene transcription. Mafa is involved either as an oncogene or as a tumor suppressor, depending on the cell context.
Product Categories/Family for anti-MAFA antibody
Polyclonal; Transcription Factor; Transcription Regulation; Transcription Factors;
Applications Tested/Suitable for anti-MAFA antibody
Western Blot (WB)
Western Blot (WB) of anti-MAFA antibody
WB Suggested Anti-Mafa Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Mouse Muscle
NCBI/Uniprot data below describe general gene information for MAFA. It may not necessarily be applicable to this product.
NCBI Accession #
NP_919331
[Other Products]
NCBI GenBank Nucleotide #
NM_194350
[Other Products]
UniProt Primary Accession #
Q8CF90
[Other Products]
UniProt Related Accession #
Q8CF90[Other Products]
NCBI Official Full Name
transcription factor MafA
NCBI Official Synonym Full Names
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)
NCBI Official Symbol
Mafa [Similar Products]
NCBI Official Synonym Symbols
RIPE3b1
[Similar Products]
NCBI Protein Information
transcription factor MafA
UniProt Protein Name
Transcription factor MafA
UniProt Synonym Protein Names
Pancreatic beta-cell-specific transcriptional activator; V-maf musculoaponeurotic fibrosarcoma oncogene homolog A
Protein Family
Transcription factor
UniProt Gene Name
Mafa [Similar Products]
UniProt Entry Name
MAFA_MOUSE
Research Articles on MAFA
1. Data suggest that hepatocytes can be reprogrammed into insulin-producing cells in vivo by transfection of neurogenin-3, Pdx1, and MafA genes using non-viral hydrodynamics injection; this procedure was used in treatment of streptozotocin diabetes; fasting blood glucose was reduced to normal. (Pdx1 = pancreatic and duodenal homeobox 1; MafA = v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A)
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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