Putative tRNAcytidine (32)/guanosine (34)-2'-O)-methyltransferase, Polyclonal A

2'-O-ribose RNA methyltransferase TRM7 homolog Protein ftsJ homolog 1 FTSJ1 JM23

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Caprylic Acid Ammonium Sulfate Precipitation purified

Liquid

Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-FTSJ1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs

This protein is a member of the S-adenosylmethionine-binding protein family. It is a nucleolar protein and may be involved in the processing and modification of rRNA. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Recommended dilution: WB:1:500-2000, IHC:1:20-1:200

All lanes: Putative tRNAcytidine(32)/guanosine(34)-2'-O)-methyltransferase antibody at 2ug/ml
Lane 1: HepG2 whole cell lysate
Lane 2: mouse brain tissue
Lane 3: EC109 whole cell lysate
Secondary
Goat polyclonal to Rabbit IgG at 1/15000 dilution
Predicted band size: 37,36 kDa
Observed band size: 16.7 kDa

Immunohistochemistry of paraffin-embedded human placenta using MBS7002593 at dilution of 1:50

35,867 Da[Similar Products]

FtsJ RNA methyltransferase homolog 1 (E. coli)

putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase

Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase

TRM7_HUMAN

This gene encodes a member of the methyltransferase superfamily. The encoded protein localizes to the nucleolus, binds to S-adenosylmethionine, and may be involved in the processing and modification of ribosomal RNA. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

FTSJ1: Defects in FTSJ1 are the cause of mental retardation X- linked type 44 (MRX44). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs. Belongs to the methyltransferase superfamily. RlmE family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Methyltransferase; EC 2.1.1.205

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: cytoplasm

Molecular Function: tRNA methyltransferase activity

Biological Process: tRNA methylation

Disease: Mental Retardation, X-linked 9

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