Product Name
SAR1B, Blocking Peptide
Full Product Name
SAR1B Blocking Peptide
Product Synonym Names
SARA2; SARB; GTP-binding protein SAR1b; GTP-binding protein B; GTBPB
Product Gene Name
SAR1B blocking peptide
[Similar Products]
SAR1B peptide (MBS8244243) is used for blocking the activity of SAR1B antibody (MBS8242587)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9Y6B6
Species Reactivity
Human, Mouse, Rat, Bovine, Pig
Form/Format
Lyophilized Powder
Quality Control
The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Other Notes
Small volumes of SAR1B blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
SAR1B blocking peptide
The peptide is used to block Anti-SAR1B Antibody reactivity.
Applications Tested/Suitable for SAR1B blocking peptide
Blocking (BL)
Application Notes for SAR1B blocking peptide
Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
NCBI/Uniprot data below describe general gene information for SAR1B. It may not necessarily be applicable to this product.
NCBI Accession #
Q9Y6B6.1
[Other Products]
UniProt Primary Accession #
Q9Y6B6
[Other Products]
UniProt Secondary Accession #
Q567T4; D3DQA4[Other Products]
UniProt Related Accession #
Q9Y6B6[Other Products]
Molecular Weight
22,410 Da
NCBI Official Full Name
GTP-binding protein SAR1b
NCBI Official Synonym Full Names
secretion associated Ras related GTPase 1B
NCBI Official Symbol
SAR1B [Similar Products]
NCBI Official Synonym Symbols
ANDD; CMRD; GTBPB; SARA2
[Similar Products]
NCBI Protein Information
GTP-binding protein SAR1b
UniProt Protein Name
GTP-binding protein SAR1b
UniProt Synonym Protein Names
GTP-binding protein B; GTBPB
Protein Family
GTP-binding protein
UniProt Gene Name
SAR1B [Similar Products]
UniProt Synonym Gene Names
SARA2; SARB; GTBPB [Similar Products]
UniProt Entry Name
SAR1B_HUMAN
NCBI Summary for SAR1B
The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]
UniProt Comments for SAR1B
SAR1B: Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex. Defects in SAR1B are the cause of chylomicron retention disease (CMRD); also known as Anderson disease (ANDD). CMRD is an autosomal recessive disorder of severe fat malabsorption associated with failure to thrive in infancy. The condition is characterized by deficiency of fat-soluble vitamins, low blood cholesterol levels, and a selective absence of chylomicrons from blood. Affected individuals accumulate chylomicron-like particles in membrane-bound compartments of enterocytes, which contain large cytosolic lipid droplets. Belongs to the small GTPase superfamily. SAR1 family.
Protein type: G protein; G protein, monomeric, SAR1; G protein, monomeric; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: cytosol; endoplasmic reticulum membrane
Molecular Function: GTP binding; GTPase activity; metal ion binding
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; intracellular protein transport; post-translational protein modification; protein amino acid N-linked glycosylation via asparagine
Disease: Chylomicron Retention Disease
Research Articles on SAR1B
1. although Sar1A antagonizes the lipoprotein secretion-promoting activity of Sar1B, both isoforms modulate the expression of genes encoding cholesterol biosynthetic enzymes and the synthesis of cholesterol de novo.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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