BMPR2, Polyclonal Antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to a region of N-terminal residues of BMPR2.

Affinity purified

1*TBS (pH7.4), 0.5%BSA, 25% Glycerol.

Store at +4 degree C after thawing. Aliquot store at-20 degree C or-80 degree C. Avoid repeated freeze/thaw cycles.

Small volumes of anti-BMPR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

BMPRII is a cell surface receptor that is part of the TGFh family of signal transduction molecules. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Similar to TGFh receptors, type I and II BMP receptors contain serine threonine kinase activity, form heteromeric complexes upon ligand stimulation, and use Smads as secondary messengers. Bone Morphogenic Proteins (BMP) are members of the TGF beta superfamily that affect bone and cartilage formation. BMPs may be an important factor for development of the viscera, with roles in cell proliferation, apoptosis, differentiation, and morphogenesis.

Western Blot (WB), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)

WB: 1:1,000-2,000

Fig: Western blot analysis on human heart tissue using anti-BMPR2

75kDa

bone morphogenetic protein receptor, type II (serine/threonine kinase)

bone morphogenetic protein receptor type-2

Bone morphogenetic protein receptor type-2

BMP type-2 receptor; BMPR-2; BMP type II receptor; BMPR-II  [Similar Products]

This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type II receptor that binds extracellular BMPs and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream to activate SMAD transcriptional regulators. This signaling is important during embryonic development. Mutations in this gene can cause pulmonary hypertension. [provided by RefSeq, Mar 2013]

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6 (PubMed:23527555).

1. YinglingJM, WangXF, BassingCH. Signalling by the transforming growth factor-receptors [J].Biochim BiophysActa, 1.95; 1.42.1.5-1.6. 2. Balemans W, Van Hul W. Extracellular regulation of BMP signling. 3. Balemans W, Van Hul W. Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators[J]. Dev Biol, 2.02. 2.0(2.:2.0-2.0.

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