Bone Morphogenetic Protein Receptor II, ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 2; NC_000002.11 (203241050..203432474). Location: 2q33-q34

Store all reagents at 2-8 degree C

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Small volumes of BMPR2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS075785 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Bone Morphogenetic Protein Receptor II (BMPR2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing BMPR2. The ELISA analytical biochemical technique of the MBS075785 kit is based on BMPR2 antibody-BMPR2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect BMPR2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, BMPR2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

115,201 Da

bone morphogenetic protein receptor, type II (serine/threonine kinase)

bone morphogenetic protein receptor type-2; BMPR-2; BMP type-2 receptor; BMP type II receptor; type II activin receptor-like kinase; bone morphogenetic protein receptor type II; type II receptor for bone morphogenetic protein-4

Bone morphogenetic protein receptor type-2

PPH1; BMP type-2 receptor; BMPR-2; BMP type II receptor; BMPR-II  [Similar Products]

BMPR2_HUMAN

This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, Jul 2008]

BMPR2: a serine/threonine-protein kinase receptor for bone morphogenetic protein (BMP). Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Defects in BMPR2 are the cause of primary pulmonary hypertension (PPH1), a weakly penetrant dominant disorder, associated with lesions in pulmonary arterioles, elevated pulmonary arterial pressure, and right ventricular failure.

Protein type: Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Cell cycle regulation; Protein kinase, TKL; EC 2.7.11.30; TKL group; STKR family; Type2 subfamily

Chromosomal Location of Human Ortholog: 2q33-q34

Cellular Component: extracellular space; cell surface; cell soma; integral to plasma membrane; cytoplasm; dendrite; apical plasma membrane; basal plasma membrane; plasma membrane; caveola

Molecular Function: transforming growth factor beta receptor activity; protein binding; metal ion binding; growth factor binding; activin receptor activity, type II; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: transcription from RNA polymerase II promoter; limb development; regulation of lung blood pressure; activin receptor signaling pathway; protein amino acid phosphorylation; BMP signaling pathway; anterior/posterior pattern formation; proteoglycan biosynthetic process; lymphangiogenesis; transmembrane receptor protein serine/threonine kinase signaling pathway; positive regulation of BMP signaling pathway; negative regulation of systemic arterial blood pressure; chondrocyte development; cellular response to starvation; positive regulation of bone mineralization; negative regulation of vasoconstriction; regulation of cell proliferation; positive regulation of osteoblast differentiation; mesoderm formation; positive regulation of axon extension involved in axon guidance; blood vessel remodeling; positive regulation of endothelial cell proliferation; brain development; negative regulation of cell growth; vascular endothelial growth factor receptor signaling pathway; alveolus development

Disease: Pulmonary Venoocclusive Disease 1, Autosomal Dominant; Pulmonary Hypertension, Primary, 1

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