Product Name
COL5A2, Polyclonal Antibody
Full Product Name
COL5A2 Antibody
Product Synonym Names
COL5A2; Collagen alpha-2(V) chain
Product Gene Name
anti-COL5A2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P05997
Specificity
COL5A2 Antibody detects endogenous levels of COL5A2 protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from the N-terminal region of human COL5A2.
Preparation and Storage
Store at -20 degree C for 1 year.
Other Notes
Small volumes of anti-COL5A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-COL5A2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-COL5A2 antibody
WB: 1:500~1:1000
ELISA: 1:10000
Western Blot (WB) of anti-COL5A2 antibody
Western Blot analysis of extracts from HepG2 cells using COL5A2 Antibody.
NCBI/Uniprot data below describe general gene information for COL5A2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000384.2
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NCBI GenBank Nucleotide #
NM_000393.4
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UniProt Primary Accession #
P05997
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UniProt Secondary Accession #
P78440; Q13908; Q53WR4; Q59GR4; Q6LDJ5; Q7KZ55; Q86XF6; Q96QB0; Q96QB3[Other Products]
UniProt Related Accession #
P05997[Other Products]
NCBI Official Full Name
collagen alpha-2(V) chain preproprotein
NCBI Official Synonym Full Names
collagen type V alpha 2 chain
NCBI Official Symbol
COL5A2 [Similar Products]
NCBI Official Synonym Symbols
EDSC; EDSCL2
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NCBI Protein Information
collagen alpha-2(V) chain
UniProt Protein Name
Collagen alpha-2(V) chain
UniProt Gene Name
COL5A2 [Similar Products]
NCBI Summary for COL5A2
This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. [provided by RefSeq, Jul 2008]
UniProt Comments for COL5A2
Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices ().
Research Articles on COL5A2
1. COL5A2(+/-) humans, although unlikely to present with frank classic Ehlers-Danlos syndrome, are likely to have fragile connective tissues with increased susceptibility to trauma and certain chronic pathologic conditions.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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