D-3-phosphoglycerate dehydrogenase, Polyclonal Antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

The antibody detects endogenous level of total D-3-phosphoglycerate dehydrogenase polyclonal antibody.

Caprylic Acid Ammonium Sulfate Precipitation purified

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

1.0 mg/ml (lot specific)

Store at -20 degree C

Small volumes of anti-PHGDH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

PHGDH or 3-phosphoglycerate dehydrogenase is an enzyme belonging to the D-isomer specific 2-hydroxyacid dehydrogenase family. It catalysis the reaction 3-phosphoglycerate + NAD+ = 3-phosphonooxypyruvate + NADH during L-serine biosynthesis. Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency). It is characterized by congenital microcephaly, psychomotor retardation and seizures.

Total protein Ab

Western Blot (WB), Immunohistochemistry (IHC)

Western Blot: 1:500 - 1:1000
Immunohistochemistry: 1:20 - 1:200

All lanes: D-3-phosphoglycerate dehydrogenase antibody at 2ug/ml

Immunohistochemical analysis of paraffin-embedded humankidney using at dilution of 1:100.

56,651 Da[Similar Products]

phosphoglycerate dehydrogenase

D-3-phosphoglycerate dehydrogenase

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SERA_HUMAN

PHGDH: Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency). It is characterized by congenital microcephaly, psychomotor retardation, and seizures. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

Protein type: Amino Acid Metabolism - glycine, serine and threonine; Cell development/differentiation; EC 1.1.1.95; Oxidoreductase

Chromosomal Location of Human Ortholog: 1p12

Cellular Component: cytosol

Molecular Function: electron carrier activity; phosphoglycerate dehydrogenase activity

Biological Process: brain development; L-serine biosynthetic process; serine family amino acid biosynthetic process

Disease: Neu-laxova Syndrome 1; Phosphoglycerate Dehydrogenase Deficiency

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