Calsequestrin 2, Polyclonal Antibody

Polyclonal Calsequestrin 2; Anti-Calsequestrin 2; FLJ26321; FLJ93514; calsequestrin-2; calsequestrin 2 fast-twitch cardiac muscle; calsequestrin 2 (cardiac muscle); Calsequestrin 2; CASQ2; Calsequestrin -2; PDIB2; calsequestrin cardiac muscle isoform

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Calsequestrin 2 antibody was purified by antigen-affinity chromatography

Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative.

0.68 mg/ml (lot specific)

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Small volumes of anti-CASQ2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Affinity purified Rabbit polyclonal Calsequestrin 2 antibody

Cardiac Markers; Purified Polyclonal Antibodies

Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

IHC-P: 1:100-1:500
WB: 1:500-1:3000

Immunohistochemical staining of paraffin-embedded Cal27 xenograft using Calsequestrin 2 antibody at a dilution of 1:500

Western blot analysis of 30 ug whole cell lysate (A:H1299) using a 10 % SDS PAGE gel and Calsequestrin 2 antibody at a dilution of 1:1000

46 kDa[Similar Products]

calsequestrin 2 (cardiac muscle)

calsequestrin-2

Calsequestrin-2

CASQ2_HUMAN

The protein encoded by this gene specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest. [provided by RefSeq, Jul 2008]

calsequestrin 2: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+) ions. Defects in CASQ2 are the cause of catecholaminergic polymorphic ventricular tachycardia type 2 (CPVT2); also known as stress-induced polymorphic ventricular tachycardia (VTSIP). CPVT2 is an autosomal recessive form of arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Belongs to the calsequestrin family.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: sarcoplasmic reticulum membrane; sarcoplasmic reticulum lumen; sarcoplasmic reticulum; cytoplasm; junctional membrane complex; voltage-gated calcium channel complex; intracellular; Z disc

Molecular Function: protein binding; protein homodimerization activity; calcium ion binding; calcium-dependent protein binding

Biological Process: protein polymerization; striated muscle contraction; regulation of heart rate; negative regulation of potassium ion transport; sequestering of calcium ion; detection of calcium ion; sarcomere organization; transmembrane transport; cardiac muscle contraction

Disease: Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/or Dilated Cardiomyopathy; Ventricular Tachycardia, Catecholaminergic Polymorphic, 2

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