Full Product Name
CBS Antibody, Biotin conjugated
Product Synonym Names
Cystathionine beta-synthaseCurated; Beta-thionase; Serine sulfhydrase; CBS
Product Gene Name
anti-CBS antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P35520
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Cystathionine beta-synthase protein (1-413AA)
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-CBS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CBS antibody
Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (PubMed:23981774, PubMed:20506325, PubMed:23974653). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).
Product Categories/Family for anti-CBS antibody
Cancer; Metabolism; Signal transduction
Applications Tested/Suitable for anti-CBS antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for CBS. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000062.1
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NCBI GenBank Nucleotide #
NM_000071.2
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UniProt Primary Accession #
P35520
[Other Products]
UniProt Secondary Accession #
Q99425; Q9BWC5; B2R993; D3DSK4[Other Products]
UniProt Related Accession #
P35520[Other Products]
Molecular Weight
61,863 Da
NCBI Official Full Name
cystathionine beta-synthase isoform 1
NCBI Official Synonym Full Names
cystathionine-beta-synthase
NCBI Official Symbol
CBS [Similar Products]
NCBI Official Synonym Symbols
HIP4
[Similar Products]
NCBI Protein Information
cystathionine beta-synthase
UniProt Protein Name
Cystathionine beta-synthase
UniProt Synonym Protein Names
Beta-thionase; Serine sulfhydrase
Protein Family
Cystathionine beta-synthase
UniProt Gene Name
CBS [Similar Products]
NCBI Summary for CBS
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]
UniProt Comments for CBS
Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (PubMed:23981774, PubMed:20506325, PubMed:23974653). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons ().
Research Articles on CBS
1. The current study observed significant differences in the frequency of the CBS 844ins68 allele across populations. There is a significant association between CBS c.844ins68 polymorphism and cleft lip and palate in the Indian population.
Precautions
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Disclaimer
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