Full Product Name
GDF-6 Polyclonal Antibody
Product Gene Name
anti-GDF-6 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q6KF10
Other Notes
Small volumes of anti-GDF-6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for GDF-6. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001001557.1
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NCBI GenBank Nucleotide #
NM_001001557.3
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UniProt Primary Accession #
Q6KF10
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UniProt Secondary Accession #
Q6PI58[Other Products]
UniProt Related Accession #
Q6KF10[Other Products]
Molecular Weight
50,662 Da
NCBI Official Full Name
growth/differentiation factor 6 preproprotein
NCBI Official Synonym Full Names
growth differentiation factor 6
NCBI Official Symbol
GDF6 [Similar Products]
NCBI Official Synonym Symbols
KFM; KFS; KFS1; KFSL; SGM1; BMP13; CDMP2; SYNS4; BMP-13
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NCBI Protein Information
growth/differentiation factor 6
UniProt Protein Name
Growth/differentiation factor 6
UniProt Synonym Protein Names
Bone morphogenetic protein 13; BMP-13; Growth/differentiation factor 16
UniProt Gene Name
GDF6 [Similar Products]
UniProt Synonym Gene Names
BMP13; GDF16; GDF-6; BMP-13 [Similar Products]
NCBI Summary for GDF-6
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene are associated with Klippel-Feil syndrome, microphthalmia, and Leber congenital amaurosis. [provided by RefSeq, Sep 2016]
UniProt Comments for GDF-6
Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map (PubMed:23307924). Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal strucutres. Seems to positively regulates differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG (PubMed:26643732). Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38 ().
Research Articles on GDF-6
1. findings indicate that increased BMP signaling owing to a GDF6 gain-of-function mutation is responsible for loss of joint formation and profound functional impairment in patients with Multiple Synostoses Syndrome 4.
Precautions
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Disclaimer
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