Product Name
HSD17B4, Blocking Peptide
Full Product Name
HSD17B4 Blocking Peptide
Product Synonym Names
EDH17B4; Peroxisomal multifunctional enzyme type 2; MFE-2; 17-beta-hydroxysteroid dehydrogenase 4; 17-beta-HSD 4; D-bifunctional protein; DBP; Multifunctional protein 2; MPF-2
Product Gene Name
HSD17B4 blocking peptide
[Similar Products]
HSD17B4 peptide (MBS8204463) is used for blocking the activity of HSD17B4 antibody (MBS8234961)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P51659
Species Reactivity
Human, Mouse, Rat, Monkey
Form/Format
Lyophilized powder
Quality Control
The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
Directions for Use
Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Other Notes
Small volumes of HSD17B4 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
HSD17B4 blocking peptide
The peptide is used to block Anti-HSD17B4 Antibody reactivity.
Applications Tested/Suitable for HSD17B4 blocking peptide
Blocking (BL)
NCBI/Uniprot data below describe general gene information for HSD17B4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000405.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000414.3
[Other Products]
UniProt Primary Accession #
P51659
[Other Products]
UniProt Secondary Accession #
B4DNV1; B4DVS5; E9PB82; F5HE57[Other Products]
UniProt Related Accession #
P51659[Other Products]
Molecular Weight
77,870 Da
NCBI Official Full Name
peroxisomal multifunctional enzyme type 2 isoform 2
NCBI Official Synonym Full Names
hydroxysteroid (17-beta) dehydrogenase 4
NCBI Official Symbol
HSD17B4 [Similar Products]
NCBI Official Synonym Symbols
DBP; MFE-2; MPF-2; PRLTS1; SDR8C1
[Similar Products]
NCBI Protein Information
peroxisomal multifunctional enzyme type 2
UniProt Protein Name
Peroxisomal multifunctional enzyme type 2
UniProt Synonym Protein Names
17-beta-hydroxysteroid dehydrogenase 4; 17-beta-HSD 4
UniProt Gene Name
HSD17B4 [Similar Products]
UniProt Synonym Gene Names
EDH17B4; SDR8C1; MFE-2; 17-beta-HSD 4; DBP; MPF-2 [Similar Products]
UniProt Entry Name
DHB4_HUMAN
NCBI Summary for HSD17B4
The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
UniProt Comments for HSD17B4
HSD17B4: Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids. Defects in HSD17B4 are a cause of D-bifunctional protein deficiency (DBPD). DBPD is a disorder of peroxisomal fatty acid beta-oxidation. Defects in HSD17B4 are the cause of Perrault syndrome (PRS). PRS is a sex-influenced disorder characterized by sensorineural deafness in both males and females and ovarian dysgenesis in females. Some patients also have neurologic manifestations, including mild mental retardation and cerebellar and peripheral nervous system involvement. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein type: Lipid Metabolism - primary bile acid biosynthesis; EC 4.2.1.107; Cell development/differentiation; Mitochondrial; Oxidoreductase; EC 1.1.1.n12; EC 4.2.1.119; Lyase
Chromosomal Location of Human Ortholog: 5q21
Cellular Component: peroxisomal membrane; peroxisomal matrix; mitochondrion; membrane; intracellular membrane-bound organelle; peroxisome
Molecular Function: protein homodimerization activity; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity; long-chain-enoyl-CoA hydratase activity; isomerase activity; 3-hydroxyacyl-CoA dehydrogenase activity; receptor binding
Biological Process: osteoblast differentiation; estrogen metabolic process; bile acid biosynthetic process; fatty acid beta-oxidation using acyl-CoA oxidase; fatty acid beta-oxidation; very-long-chain fatty acid metabolic process; bile acid metabolic process; metabolic process; unsaturated fatty acid metabolic process; androgen metabolic process; cellular lipid metabolic process; Sertoli cell development
Disease: Perrault Syndrome 1; D-bifunctional Protein Deficiency
Research Articles on HSD17B4
1. Structural MFE-2 instability is the molecular basis of D-bifunctional protein deficiency type III.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
