Product Name
SAR1B, Blocking Peptide
Full Product Name
SAR1B Peptide - middle region
Product Gene Name
SAR1B blocking peptide
[Similar Products]
Product Synonym Gene Name
ANDD; CMRD; GTBPB; SARA2[Similar Products]
SAR1B peptide (MBS3245459) is used for blocking the activity of SAR1B antibody (MBS3220657)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
Synthetic peptide located within the following region: RPEAISEERL REMFGLYGQT TGKGSISLKE LNARPLEVFM CSVLKRQGYG
3D Structure
ModBase 3D Structure for Q9Y6B6
Form/Format
Lyophilized powder
Preparation and Storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of SAR1B blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
SAR1B blocking peptide
The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene.
Product Categories/Family for SAR1B blocking peptide
Peptide
Applications Tested/Suitable for SAR1B blocking peptide
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for SAR1B. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001028675.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001033503.2
[Other Products]
UniProt Primary Accession #
Q9Y6B6
[Other Products]
UniProt Related Accession #
Q9Y6B6[Other Products]
NCBI Official Full Name
GTP-binding protein SAR1b
NCBI Official Synonym Full Names
secretion associated Ras related GTPase 1B
NCBI Official Symbol
SAR1B [Similar Products]
NCBI Official Synonym Symbols
ANDD; CMRD; GTBPB; SARA2
[Similar Products]
NCBI Protein Information
GTP-binding protein SAR1b
UniProt Protein Name
GTP-binding protein SAR1b
UniProt Synonym Protein Names
GTP-binding protein B
Protein Family
GTP-binding protein
UniProt Gene Name
SAR1B [Similar Products]
UniProt Synonym Gene Names
SARA2; SARB; GTBPB [Similar Products]
UniProt Entry Name
SAR1B_HUMAN
NCBI Summary for SAR1B
The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]
UniProt Comments for SAR1B
SAR1B: Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex. Defects in SAR1B are the cause of chylomicron retention disease (CMRD); also known as Anderson disease (ANDD). CMRD is an autosomal recessive disorder of severe fat malabsorption associated with failure to thrive in infancy. The condition is characterized by deficiency of fat-soluble vitamins, low blood cholesterol levels, and a selective absence of chylomicrons from blood. Affected individuals accumulate chylomicron-like particles in membrane-bound compartments of enterocytes, which contain large cytosolic lipid droplets. Belongs to the small GTPase superfamily. SAR1 family.
Protein type: G protein, monomeric; G protein; G protein, monomeric, SAR1; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: endoplasmic reticulum membrane; cytosol
Molecular Function: GTPase activity; GTP binding; metal ion binding
Biological Process: COPII coating of Golgi vesicle; intracellular protein transport; ER to Golgi vesicle-mediated transport; antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification
Disease: Chylomicron Retention Disease
Research Articles on SAR1B
1. Study data suggest that SAR1A and SAR1B are the critical regulators of trafficking of Nav1.5. Moreover, SAR1A and SAR1B interact with MOG1, and are required for MOG1-mediated cell surface expression and function of Nav1.5.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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