ATP2A1, Monoclonal Antibody

ATP2A; SERCA1

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG1

3D1H6

Mouse

Small volumes of anti-ATP2A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Flow Cytometry (FC/FACS)

Western blot using Recombinant protein
Western blot using Transfection expressed protein
Western blot using Cell lysate

110kDa

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1

sarcoplasmic/endoplasmic reticulum calcium ATPase 1

Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

SERCA1; SR Ca(2+)-ATPase 1  [Similar Products]

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Oct 2013]

Key regulator of striated muscle performance by acting as the major Ca2+ ATPase responsible for the reuptake of cytosolic Ca2+ into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.

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