B3GALTL, Polyclonal Antibody

B3GTL; Beta-1,3-glucosyltransferase; Beta3Glc-T; Beta-3-glycosyltransferase-like

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Recognizes endogenous levels of B3GALTL protein.

The antibody was purified by immunogen affinity chromatography.

Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Small volumes of anti-B3GALTL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Rabbit polyclonal antibody to B3GALTL

Western Blot (WB), Immunohistochemistry (IHC)

Western Blot: (1/500 - 1/1000); Immunohistochemistry: (1/100 - 1/200)

Western blot analysis of B3GALTL expression in HEK293T (A), MCF7 (B), HepG2 (C) whole cell lysates.

Immunohistochemical analysis of B3GALTL staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

56,564 Da

beta 3-glucosyltransferase

beta-1,3-glucosyltransferase

Beta-1,3-glucosyltransferase

Beta3Glc-T  [Similar Products]

B3GLT_HUMAN

The protein encoded by this gene is a beta-1,3-glucosyltransferase that transfers glucose to O-linked fucosylglycans on thrombospondin type-1 repeats (TSRs) of several proteins. The encoded protein is a type II membrane protein. Defects in this gene are a cause of Peters-plus syndrome (PPS).[provided by RefSeq, Mar 2009]

B3GALTL: O-fucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan. Defects in B3GALTL are the cause of Peters-plus syndrome (PpS). PpS is an autosomal recessive disorder characterized by anterior eye-chamber abnormalities, disproportionate short stature, developmental delay, characteristic craniofacial features, cleft lip and/or palate. Belongs to the glycosyltransferase 31 family.

Protein type: Membrane protein, integral; EC 2.4.1.-; Transferase

Chromosomal Location of Human Ortholog: 13q12.3

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function: transferase activity, transferring glycosyl groups

Biological Process: cellular protein metabolic process; fucose metabolic process; post-translational protein modification; protein amino acid O-linked glycosylation

Disease: Peters-plus Syndrome

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