Product Name
Gap junction beta-2 protein (Gjb2), Recombinant Protein
Full Product Name
Recombinant Rat Gap junction beta-2 protein (Gjb2)
Product Synonym Names
Recombinant Gap junction beta-2 protein (Gjb2); Gap junction beta-2 protein; Connexin-26; Cx26
Product Gene Name
Gjb2 recombinant protein
[Similar Products]
Product Synonym Gene Name
Gjb2; Cxn-26[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MDWGTLQSIL GGVNKHSTSI GKIWLTVLFI FRIMILVVAA KEVWGDEQAD FVCNTLQPGC KNVCYDHYFP ISHIRLWALQ LIMVSTPALL VAMHVAYRRH EKKRKFMKGE IKNEFKDIEE IKTQKVRIEG SLWWTYTTSI FFRVIFEAVF MYVFYIMYNG FFMQRLVKCN AWPCPNTVDC FISRPTEKTV FTVFMISVSG ICILLNITEL CYLFIRYCSG KSKRPV
Chromosome Location
Chromosome: 15; NC_005114.3 (41224497..41230461, complement). Location: 15p12
3D Structure
ModBase 3D Structure for P21994
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Rattus norvegicus (Rat)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Gjb2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Gjb2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001004099.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001004099.1
[Other Products]
UniProt Primary Accession #
P21994
[Other Products]
UniProt Related Accession #
P21994[Other Products]
Molecular Weight
26,451 Da[Similar Products]
NCBI Official Full Name
gap junction beta-2 protein
NCBI Official Synonym Full Names
gap junction protein, beta 2
NCBI Official Symbol
Gjb2 [Similar Products]
NCBI Official Synonym Symbols
Cx26; CXN-26
[Similar Products]
NCBI Protein Information
gap junction beta-2 protein; connexin 26; connexin-26; gap junction channel protein connexin 26; gap junction membrane channel protein beta 2
UniProt Protein Name
Gap junction beta-2 protein
UniProt Synonym Protein Names
Connexin-26
Protein Family
Gap junction beta-2 protein
UniProt Gene Name
Gjb2 [Similar Products]
UniProt Synonym Gene Names
Cxn-26; Cx26 [Similar Products]
UniProt Entry Name
CXB2_RAT
NCBI Summary for Gjb2
forms gap junctions; may play a role in epididymal development [RGD, Feb 2006]
UniProt Comments for Gjb2
Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subunit structure: A connexon is composed of a hexamer of connexins. Interacts with CNST
By similarity.
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction › gap junction.
Tissue specificity: Liver, kidney, intestine, lung, spleen, stomach, testis and brain, but not heart and ***** skeletal muscle.
Sequence similarities: Belongs to the connexin family. Beta-type (group I) subfamily.
Research Articles on Gjb2
1. Changes in Cx43 expression following engraftment of neural stem cells to striatal tissue.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
