alpha 1-Antichymotrypsin, Polyclonal Antibody

Affinity Purified Goat anti-Human Alpha 1-Antichymotrypsin; anti-Human alpha 1-Antichymotrypsin

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 14; NC_000014.8 (95078714..95090390). Location: 14q32.1

Polyclonal

Goat

Unconjugated A.P.

Liquid

Store at 4 degree C.
Shelf Life: 24 months after shipping date.

Small volumes of anti-SERPINA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Goats were immunized with highly purified human Alpha 1-Antichymotrypsin. The resulting antiserum was passed over an antigen containing immunoabsorbant from which the anti-human Alpha 1-Antichymotrypsin was immunoaffinity purified.

Human Protein

This product is specific for alpha 1-Antichymotrypsin by ELISA, immunodiffusion and IEP analysis. No reaction with other human proteins is observed.

47,651 Da[Similar Products]

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3

alpha-1-antichymotrypsin; serpin A3; OTTHUMP00000028439; growth-inhibiting protein 24; growth-inhibiting protein 25; cell growth-inhibiting gene 24/25 protein; serine (or cysteine) proteinase inhibitor, clade A, member 3

Alpha-1-antichymotrypsin

AACT  [Similar Products]

AACT_HUMAN

The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq]

SERPINA3: Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: extracellular space; extracellular region; intracellular; nucleus

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; DNA binding

Biological Process: regulation of lipid metabolic process; maintenance of gastrointestinal epithelium; acute-phase response; inflammatory response

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