Full Product Name
CD42d Polyclonal Antibody
Product Gene Name
anti-CD42d antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P40197
Other Notes
Small volumes of anti-CD42d antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CD42d. It may not necessarily be applicable to this product.
NCBI Accession #
NP_004479.1
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NCBI GenBank Nucleotide #
NM_004488.2
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UniProt Primary Accession #
P40197
[Other Products]
UniProt Secondary Accession #
D1MER9[Other Products]
UniProt Related Accession #
P40197[Other Products]
Molecular Weight
60,959 Da
NCBI Official Full Name
platelet glycoprotein V
NCBI Official Synonym Full Names
glycoprotein V platelet
NCBI Official Symbol
GP5 [Similar Products]
NCBI Official Synonym Symbols
GPV; CD42d
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NCBI Protein Information
platelet glycoprotein V
UniProt Protein Name
Platelet glycoprotein V
UniProt Synonym Protein Names
Glycoprotein 5; CD_antigen: CD42d
UniProt Gene Name
GP5 [Similar Products]
UniProt Synonym Gene Names
GPV [Similar Products]
NCBI Summary for CD42d
Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM, Nov 2010]
UniProt Comments for CD42d
The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.
Research Articles on CD42d
1. Studies indicate that platelets from Bernard-Soulier syndrome (BSS) are defective in glycoprotein (GP)Ib-IX-V, a platelet-specific adhesion-signaling complex, composed of GPIbalpha disulfide linked to GPIbbeta, and noncovalently associated with GPIX and GPV.
Precautions
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Disclaimer
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