Full Product Name
DTX1 (Deltex Homolog 1, Deltex-1)
Product Synonym Names
Anti -DTX1 (Deltex Homolog 1, Deltex-1)
Product Gene Name
anti-DTX1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 12; NC_000012.11 (113495662..113535833). Location: 12q24.13
3D Structure
ModBase 3D Structure for Q86Y01
Specificity
Recognizes DTX1. Species sequence homology: human, mouse, rat, canine, bovine.
Purity/Purification
Affinity Purified
Purified by peptide affinity chromatography.
Form/Format
Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Immunogen
Synthetic peptide corresponding to CHHIENVLKEDAR, from the internal region (near N Terminus) of human DTX-1 (NP_004407.2).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-DTX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DTX1 antibody
Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity.
Product Categories/Family for anti-DTX1 antibody
Antibodies; Abs to Notch Proteins
Applications Tested/Suitable for anti-DTX1 antibody
ELISA (EL/EIA)
Application Notes for anti-DTX1 antibody
Suitable for use in ELISA.
Dilution: Peptide ELISA Titer: 1:8000
NCBI/Uniprot data below describe general gene information for DTX1. It may not necessarily be applicable to this product.
UniProt Primary Accession #
Q86Y01
[Other Products]
UniProt Secondary Accession #
O60630; Q9BS04[Other Products]
UniProt Related Accession #
Q86Y01[Other Products]
Molecular Weight
67,368 Da[Similar Products]
NCBI Official Full Name
DTX1 protein
NCBI Official Synonym Full Names
deltex homolog 1 (Drosophila)
NCBI Official Symbol
DTX1 [Similar Products]
NCBI Official Synonym Symbols
hDx-1
[Similar Products]
NCBI Protein Information
protein deltex-1; hDTX1; deltex1
UniProt Protein Name
Protein deltex-1
Protein Family
Protein DETOXIFICATION
UniProt Gene Name
DTX1 [Similar Products]
UniProt Entry Name
DTX1_HUMAN
NCBI Summary for DTX1
Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. [provided by RefSeq]
UniProt Comments for DTX1
DTX1: Functions as an ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T- cell development, suggesting that it can antagonize NOTCH1. Belongs to the Deltex family.
Protein type: Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.-; Ligase
Chromosomal Location of Human Ortholog: 12q24.13
Cellular Component: cytoplasm; nucleus; cytosol
Molecular Function: protein binding; zinc ion binding; ubiquitin protein ligase binding; transcription coactivator activity; Notch binding; SH3 domain binding; ligase activity
Biological Process: transcription from RNA polymerase II promoter; Notch signaling pathway; negative regulation of neuron differentiation; glial cell differentiation; cell surface receptor linked signal transduction; transcription, DNA-dependent; regulation of Notch signaling pathway; protein ubiquitination; negative regulation of T cell differentiation
Research Articles on DTX1
1. characterization of two genes expressed in centroblasts of human tonsils: deltex (Drosophila) homolog 1 (DTX1), which is related to the Notch pathway and a new Kelch-like protein, KLHL6
Precautions
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Disclaimer
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