RDH5, Blocking Peptide

RDH5; retinol dehydrogenase 5 (11-cis/9-cis); FLJ39337; FLJ97089; HSD17B9; RDH1; SDR9C5; 11-cis RDH; 9-cis-retinol specific dehydrogenase; retinol dehydrogenase 1; retinol dehydrogenase 5 (11-cis and 9-cis); short chain dehydrogenase/reductase family 9C,

For Research Use Only. Not for use in diagnostic procedures.

100ug of dried peptide

Shipped at ambient temperature, store at -20 degree C

Manufactured in an ISO 9001:2008 Certified Laboratory.

Small volumes of RDH5 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

34,979 Da

retinol dehydrogenase 5

11-cis retinol dehydrogenase

11-cis retinol dehydrogenase

HSD17B9; RDH1; SDR9C5; 11-cis RDH; 11-cis RoDH; 9cRDH  [Similar Products]

RDH1_HUMAN

This gene encodes an enzyme belonging to the short-chain dehydrogenases/reductases (SDR) family. This retinol dehydrogenase functions to catalyze the final step in the biosynthesis of 11-cis retinaldehyde, which is the universal chromophore of visual pigments. Mutations in this gene cause autosomal recessive fundus albipunctatus, a rare form of night blindness that is characterized by a delay in the regeneration of cone and rod photopigments. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S1 (biogenesis of lysosomal organelles complex-1, subunit 1) gene. [provided by RefSeq, Dec 2010]

RDH5: Stereospecific 11-cis retinol dehydrogenase, which catalyzes the final step in the biosynthesis of 11-cis retinaldehyde, the universal chromophore of visual pigments. Also able to oxidize 9-cis-retinol and 13-cis-retinol, but not all- trans-retinol. Active in the presence of NAD as cofactor but not in the presence of NADP. Defects in RDH5 are a cause of retinitis punctata albescens (RPA); also known as fundus albipunctatus (FA). RPA is a rare form of stationary night blindness characterized by a delay in the regeneration of cone and rod photopigments. Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Protein type: EC 1.1.1.315; Cofactor and Vitamin Metabolism - retinol; Endoplasmic reticulum; Oxidoreductase

Chromosomal Location of Human Ortholog: 12q13-q14

Cellular Component: endoplasmic reticulum lumen; endoplasmic reticulum membrane

Molecular Function: retinol dehydrogenase activity

Biological Process: response to stimulus; retinoid metabolic process; retinol metabolic process; visual perception

Disease: Fundus Albipunctatus

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