AurA, Antibody

AIK; ARK1; AYK1; Aurora-A; Aurora-family kinase 1; Aurora-related kinase 1; Aurora/IPL1-related kinase 1; BTAK; Breast-tumor-amplified kinase; EC 2.7.11.1; IAK1; Ipl1-and aurora-related kinase 1; STK15; STK6; Serine/threonine kinase 15; Serine/threonine kinase 6; Serine/threonine kinase Ayk1; kinase AurA

For Research Use Only. Not for use in diagnostic procedures.

AurA (Phospho-Ser342) antibody detects endogenous levels of AurA only when phosphorylated at serine 342.

Affinity-purified fromrabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at-20 degree C for 1 year.

Small volumes of anti-AurA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

Immunohistochemistry (IHC), ELISA (EIA)

IHC: 1:50-1:100
ELISA: 1:1000

P-peptide-+

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using AurA (Phospho-Ser342) antibody. AurA (Phospho-Ser342) antibody reacts with epitope-specific phosphopeptide and corresponding non-phosphopeptide. The absorbance readings at 450 nM are shown in the ELISA figure.

45,809 Da

aurora kinase A

aurora kinase A

Aurora kinase A

AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6; ARK-1; Aurora-related kinase 1; hARK1  [Similar Products]

The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.

Elizabeth A. Rowley. Journal of Refugee Studies, Jun 2006; 19: 158-186. GERVASE CLARENCE-SMITH. Afr. Aff. (Lond), Apr 1986; 85: 310-311. Michael Bratton. Afr. Aff. (Lond), Jul 2001; 100: 429-452.

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