Adiponutrin, Polyclonal Antibody

Anti -Adiponutrin (PNPLA3, Patatin-like Phospholipase Domain-containing Protein 3, Acylglycerol O-acyltransferase, Calcium-independent Phospholipase A2-epsilon, iPLA2-epsilon, Pnpla3, Adpn)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 22; NC_000022.10 (44319619..44343451). Location: 22q13.31

Polyclonal

Goat

Recognizes mouse PNPLA3. Species sequence homology: Canine, human, porcine and rat.

Affinity Purified
Purified by immunoaffinity chromatography.

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-PNPLA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities.

Antibodies; Abs to Enzymes, Acyltransferase

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

Suitable for use in ELISA, Immunohistochemistry and Western Blot.
Dilution: ELISA: 1:128,000
Immunohistochemistry (Paraffin): 4-6ug/ml
Western Blot: 0.05-0.2ug/ml, observed in mouse heart lysates on ~45kD bands

52,865 Da[Similar Products]

patatin-like phospholipase domain containing 3

patatin-like phospholipase domain-containing protein 3; adiponutrin; iPLA2epsilon; iPLA2-epsilon; acylglycerol O-acyltransferase; calcium-independent phospholipase A2-epsilon

Patatin-like phospholipase domain-containing protein 3

ADPN; C22orf20; iPLA2-epsilon  [Similar Products]

PLPL3_HUMAN

The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008]

PNPLA3: Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities. Genetic variations in PNPLA3 are a cause of susceptibility to non-alcoholic fatty liver disease type 1 (NAFLD1). A condition characterized by an accumulation of excess triglyceride in the liver, a condition known as hepatic steatosis (or fatty liver), which is associated with adverse metabolic consequences, including insulin resistance and dyslipidemia. In a subset of individuals, hepatic steatosis promotes an inflammatory response in the liver, referred to as steatohepatitis, which can progress to cirrhosis and liver cancer. NAFLD is the most common form of liver disease in Western countries. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.1.3; Phospholipase; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - glycerolipid; Transferase; Secondary Metabolites Metabolism - limonene and pinene degradation; Amino Acid Metabolism - phenylalanine; Membrane protein, integral; Amino Acid Metabolism - tyrosine

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: endoplasmic reticulum membrane; membrane; integral to membrane

Molecular Function: phospholipase A2 activity; triacylglycerol lipase activity; mono-olein transacylation activity; diolein transacylation activity

Biological Process: phospholipid metabolic process; triacylglycerol catabolic process; glycerophospholipid biosynthetic process; triacylglycerol biosynthetic process

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