AurA, ELISA Kit

AIK; ARK1; Aurora-A; Aurora-family kinase 1; Aurora-related kinase 1; Aurora/IPL1-related kinase 1; AYK1; Breast-tumor-amplified kinase; BTAK; IAK1; Ipl1- and aurora-related kinase 1; kinase AurA; Serine/threonine kinase 15; Serine/threonine kinase 6; Serine/threonine kinase Ayk1; STK15; STK6

For Research Use Only. Not for use in diagnostic procedures.

One 96-Well Plate

Store at 4 degree C.

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of AurA elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9500051 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the AurA, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing AurA. The ELISA analytical biochemical technique of the MBS9500051 kit is based on AurA antibody-AurA antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect AurA antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, AurA. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Cell Based ELISA Kit

45809

aurora kinase A

aurora kinase A

Aurora kinase A

AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6; ARK-1; Aurora-related kinase 1; hARK1  [Similar Products]

The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

AurA: a member of the AUR family of kinases. A cell cycle-regulated serine/threonine protein kinase that is overexpressed in many tumor cell lines. Regulated by phosphorylation-dependent proteasomal degradation. Localized to mitotic centrosomes and spindle microtubules and is required for centrosome maturation. Loss of Aurora A leads to defective mitotic spindles and gross errors in chromosome segregation. Required for centrosome duplication and chromosome segregation. Overexpression in culture drives transformation and aneuploidy, and negatively regulates p53. Amplified or overexpressed in many tumors or cell lines. Found as a skin tumor susceptibility gene in mouse, and a human SNP in a degradation domain is weakly cancer-associated and undergoes allele-specific amplification. Inhibitors: VX-680, ZM447439, Hesperadin, SNS-595.

Protein type: AUR family; EC 2.7.11.1; Kinase, protein; Oncoprotein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 20q13.2

Cellular Component: axon hillock; centriole; centrosome; cilium; condensed nuclear chromosome, centromeric region; cytosol; germinal vesicle; microtubule cytoskeleton; midbody; nucleoplasm; nucleus; perinuclear region of cytoplasm; pronucleus; spindle; spindle microtubule; spindle midzone; spindle pole centrosome

Molecular Function: ATP binding; histone serine kinase activity; protein binding; protein heterodimerization activity; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; ubiquitin protein ligase binding

Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; anterior/posterior axis specification; cell division; centrosome localization; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; G2/M transition of mitotic cell cycle; mitotic cell cycle; mitotic centrosome separation; mitotic spindle organization and biogenesis; negative regulation of apoptosis; negative regulation of G2/M transition of mitotic cell cycle; negative regulation of protein binding; positive regulation of mitotic nuclear division; positive regulation of oocyte maturation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein amino acid phosphorylation; protein autophosphorylation; protein localization to centrosome; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of centrosome cycle; regulation of cytokinesis; regulation of G2/M transition of mitotic cell cycle; regulation of protein stability; response to wounding; spindle assembly involved in female meiosis I; spindle organization and biogenesis

Disease: Colorectal Cancer

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